美西律
別名: Mexitil, Mexilen, Mexitilen, Myovek, Ritalmex
藥物類別: Antiarrhythmic (Class IB)
- **務必隨餐餵食**：此藥物極易引起胃部不適、噁心和嘔吐。與豐盛的食物一起服用可大幅降低此風險。 - **嚴格遵守給藥時間**：請務必按照獸醫師指示給藥，切勿自行跳過劑量或停藥。心室性心律不整可能危及生命，若中斷藥物，心律不整可能會迅速復發。 - **觀察副作用**：如果您的寵物出現持續嘔吐、顫抖、步態不穩、頭暈、極度疲倦或呼吸急促，請立即聯繫您的獸醫師。
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Treating or assisting in treatment of ventricular arrhythmias
- Treating or assisting in treatment of ventricular arrhythmias
- Ventricular arrhythmias in Boxers
- Treating or assisting in treatment of ventricular arrhythmias
- Familial arrhythmic cardiomyopathy of Boxers (ARVC)
- Treating or assisting in treatment of ventricular arrhythmias
- Myotonia congenita or myokymia
給藥方式
PO
可能的副作用
- Vomiting (very common)
- Nausea
- Trembling/Tremors
- Unsteadiness/Ataxia
- Dizziness
- Depression/Lethargy
- Shortness of breath
- Proarrhythmia (PVCs)
- Chest pain
- Seizures (rare)
- Agranulocytosis (rare)
- Thrombocytopenia (rare)
注意事項與禁忌
- Pre-existing 2nd or 3rd degree AV block (without a pacemaker)
- Cardiogenic shock
- Known hypersensitivity to mexiletine
- Use with **extreme caution** in patients with severe congestive heart failure, acute myocardial infarction, hepatic function impairment, hypotension, intraventricular conduction abnormalities, sinus node function impairment, or a pre-existing seizure disorder. > **Clinical Note**: Mexiletine is secreted into maternal milk; use of a milk replacer is recommended if the nursing mother is receiving the drug. FDA Pregnancy Category C.
藥物相互作用
- Antacids (Aluminum-Magnesium): May slow the absorption of mexiletine.
- Atropine: May reduce the rate of oral absorption.
- Cimetidine: May increase or decrease mexiletine blood levels.
- Griseofulvin: May accelerate the metabolism of mexiletine.
- Lidocaine: May cause additive adverse effects (especially CNS toxicity).
- Metoclopramide: May accelerate the absorption of mexiletine.
- Opiates: May slow the absorption of mexiletine.
- Phenobarbital: May accelerate the metabolism of mexiletine.
- Primidone: May accelerate the metabolism of mexiletine.
- Phenytoin: May accelerate the metabolism of mexiletine.
- Rifampin: May accelerate the metabolism of mexiletine.
- Theophylline: Mexiletine may reduce the metabolism of theophylline, potentially leading to theophylline toxicity.
- Urinary Acidifying Drugs (e.g., methionine, ammonium chloride): May accelerate the renal excretion of mexiletine.
- Urinary Alkalinizing Drugs (e.g., citrates, sodium bicarbonate): May reduce the urinary excretion of mexiletine.
常見問題
美西律用於寵物有甚麼用途？
- 務必隨餐餵食：此藥物極易引起胃部不適、噁心和嘔吐。與豐盛的食物一起服用可大幅降低此風險。 - 嚴格遵守給藥時間：請務必按照獸醫師指示給藥，切勿自行跳過劑量或停藥。心室性心律不整可能危及生命，若中斷藥物，心律不整可能會迅速復發。 - 觀察副作用：如果您的寵物出現持續嘔吐、顫抖、步態不穩、頭暈、極度疲倦或呼吸急促，請立即聯繫您的獸醫師。
美西律對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。