Mexiletine
別名: Mexitil, Mexilen, Mexitilen, Myovek, Ritalmex
- **Always give with food**: This medication frequently causes stomach upset, nausea, and vomiting. Giving it with a full meal significantly reduces this risk. - **Strict Adherence**: Do not skip doses or stop the medication without consulting your veterinarian. Ventricular arrhythmias can be life-threatening and may return rapidly if the drug is discontinued. - **Monitor for Side Effects**: Contact your veterinarian immediately if your pet experiences persistent vomiting, trembling, unsteadiness, dizziness, extreme lethargy, or shortness of breath.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Treating or assisting in treatment of ventricular arrhythmias
- Treating or assisting in treatment of ventricular arrhythmias
- Ventricular arrhythmias in Boxers
- Treating or assisting in treatment of ventricular arrhythmias
- Familial arrhythmic cardiomyopathy of Boxers (ARVC)
- Treating or assisting in treatment of ventricular arrhythmias
- Myotonia congenita or myokymia
給藥方式
可能的副作用
- Vomiting (very common)
- Nausea
- Trembling/Tremors
- Unsteadiness/Ataxia
- Dizziness
- Depression/Lethargy
- Shortness of breath
- Proarrhythmia (PVCs)
- Chest pain
- Seizures (rare)
- Agranulocytosis (rare)
- Thrombocytopenia (rare)
注意事項與禁忌
- Pre-existing 2nd or 3rd degree AV block (without a pacemaker)
- Cardiogenic shock
- Known hypersensitivity to mexiletine
- Use with **extreme caution** in patients with severe congestive heart failure, acute myocardial infarction, hepatic function impairment, hypotension, intraventricular conduction abnormalities, sinus node function impairment, or a pre-existing seizure disorder. > **Clinical Note**: Mexiletine is secreted into maternal milk; use of a milk replacer is recommended if the nursing mother is receiving the drug. FDA Pregnancy Category C.
藥物相互作用
- Antacids (Aluminum-Magnesium): May slow the absorption of mexiletine.
- Atropine: May reduce the rate of oral absorption.
- Cimetidine: May increase or decrease mexiletine blood levels.
- Griseofulvin: May accelerate the metabolism of mexiletine.
- Lidocaine: May cause additive adverse effects (especially CNS toxicity).
- Metoclopramide: May accelerate the absorption of mexiletine.
- Opiates: May slow the absorption of mexiletine.
- Phenobarbital: May accelerate the metabolism of mexiletine.
- Primidone: May accelerate the metabolism of mexiletine.
- Phenytoin: May accelerate the metabolism of mexiletine.
- Rifampin: May accelerate the metabolism of mexiletine.
- Theophylline: Mexiletine may reduce the metabolism of theophylline, potentially leading to theophylline toxicity.
常見問題
Mexiletine用於寵物有甚麼用途？
- **Always give with food**: This medication frequently causes stomach upset, nausea, and vomiting. Giving it with a full meal significantly reduces this risk. - **Strict Adherence**: Do not skip doses or stop the medication without consulting your veterinarian. Ventricular arrhythmias can be life-threatening and may return rapidly if the drug is discontinued. - **Monitor for Side Effects**: Contact your veterinarian immediately if your pet experiences persistent vomiting, trembling, unsteadiness, dizziness, extreme lethargy, or shortness of breath.
Mexiletine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。