Methylprednisolone
別名: Medrol, Depo-Medrol, Solu-Medrol, A-Methapred, Depo-Medrone, Medrone, Solu-Medrone
**Important Guidelines for Pet Owners:** * **Do Not Stop Abruptly:** Never discontinue this medication suddenly without consulting your veterinarian. The body's natural steroid production goes to sleep while on this drug, and stopping abruptly can cause a life-threatening crisis. Your vet will provide a tapering schedule. * **Expected Side Effects:** It is very common for pets to drink more water, urinate more frequently, and have an increased appetite while on this medication. Ensure they always have access to fresh water and frequent bathroom breaks. * **Watch for Severe Signs:** Contact your veterinarian if you notice severe side effects such as vomiting, dark/tarry stools, bloody diarrhea, extreme lethargy, panting, or significant behavioral changes. * **Follow Instructions:** Give the medication exactly as prescribed. If using an alternate-day schedule, it may be helpful to mark a calendar to avoid missing doses.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Labeled uses (Oral)
- Labeled uses (Injectable)
- Intralesional (sub-lesional) use
- Antiinflammatory (glucocorticoid effects)
- Intra-articular use
- Labeled uses (Oral)
- Labeled uses (Injectable)
- Intralesional (sub-lesional) use
給藥方式
可能的副作用
- Polyuria (PU), polydipsia (PD), polyphagia (PP)
- Iatrogenic hyperadrenocorticism (Cushingoid signs) with sustained use
- HPA axis suppression
- Weight gain and lipidemias
- Dull, dry haircoat and alopecia
- Muscle wasting and weakness
- Gastrointestinal ulceration, vomiting, diarrhea, melena, hematochezia
- Elevated liver enzymes (ALP, ALT) and hepatopathy
- Pancreatitis
- Activation or worsening of diabetes mellitus (especially in cats)
- Behavioral changes (depression, lethargy, viciousness, panting)
- Extracellular hyperglycemia leading to volume expansion and potential CHF (cats)
- Hypothalamic-pituitary-adrenal (HPA) axis suppression
注意事項與禁忌
- Systemic fungal infections (unless used for Addison's replacement)
- Viral infections
- Arrested tuberculosis
- Peptic or corneal ulcers
- Acute psychoses
- Cushingoid syndrome
- Idiopathic thrombocytopenia (for IM administration)
- Acute local infections (for intrasynovial/intratendinous use)
- Chronic systemic therapy using sustained-release injectable forms
- Pregnant animals
- Renal disease
- Diabetes mellitus
- > **Tapering Required:** Animals receiving systemic glucocorticoids (other than short 'burst' therapy) must be tapered off slowly to allow endogenous ACTH and corticosteroid function to recover. Abrupt withdrawal can precipitate an Addisonian crisis. * **Stress Dosing:** Additional glucocorticoids may be needed during stressors (surgery, trauma, illness) during the tapering process. * **Use with Caution:** In patients with diabetes mellitus, osteoporosis, predisposition to thrombophlebitis, hypertension, congestive heart failure (CHF), and renal insufficiency. * **Pregnancy:** FDA Category C. May cause teratogenic effects in early pregnancy. Exogenous steroids can induce parturition in the latter stages of pregnancy in horses and ruminants. * **Nursing Dams:** Glucocorticoids enter milk and may inhibit growth or interfere with endogenous corticosteroid production in nursing offspring.
藥物相互作用
- Amphotericin B: May cause hypokalemia; potential for CHF and cardiac enlargement
- Analgesics/Opiates/Local Anesthetics (epidural): Combination in epidurals has caused serious CNS injuries and death
- Anticholinesterase agents (e.g., pyridostigmine): May lead to profound muscle weakness in myasthenia gravis patients
- Aspirin: Glucocorticoids may reduce salicylate blood levels
- Barbiturates: May increase the metabolism of glucocorticoids and decrease blood levels
- Cyclophosphamide: Glucocorticoids may inhibit hepatic metabolism of cyclophosphamide
- Cyclosporine: May mutually inhibit hepatic metabolism, increasing blood levels of both drugs
- Potassium-depleting diuretics: May cause hypokalemia
- Ephedrine: May reduce methylprednisolone blood levels
- Estrogens: May potentiate the effects of methylprednisolone
- Insulin: Insulin requirements may increase due to glucocorticoid-induced insulin resistance
常見問題
Methylprednisolone用於寵物有甚麼用途？
**Important Guidelines for Pet Owners:** * **Do Not Stop Abruptly:** Never discontinue this medication suddenly without consulting your veterinarian. The body's natural steroid production goes to sleep while on this drug, and stopping abruptly can cause a life-threatening crisis. Your vet will provide a tapering schedule. * **Expected Side Effects:** It is very common for pets to drink more water, urinate more frequently, and have an increased appetite while on this medication. Ensure they always have access to fresh water and frequent bathroom breaks. * **Watch for Severe Signs:** Contact your veterinarian if you notice severe side effects such as vomiting, dark/tarry stools, bloody diarrhea, extreme lethargy, panting, or significant behavioral changes. * **Follow Instructions:** Give the medication exactly as prescribed. If using an alternate-day schedule, it may be helpful to mark a calendar to avoid missing doses.
Methylprednisolone對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。