Fomepizole
別名: Antizol, Antizol-Vet
> **Medical Emergency**: Antifreeze (ethylene glycol) poisoning is a life-threatening emergency. Time is absolutely critical. * **Rapid Action Needed**: Dogs treated within 8 hours of ingestion have a much better chance of survival. Cats are extremely sensitive and must be treated within **3 hours** of ingestion. * **Intensive Care**: Treatment requires hospitalization in an intensive care setting. Your pet will need IV fluids, frequent blood tests, and close monitoring. * **Cost**: The antidote (fomepizole) and the associated intensive care can be quite expensive, especially for large dogs. You will need to make an informed decision rapidly to give your pet the best chance of survival.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- For treatment of ethylene glycol toxicity
- For treatment of ethylene glycol toxicity
給藥方式
可能的副作用
- Vein irritation and phlebosclerosis (if given rapidly or undiluted)
- Anaphylaxis (rare)
- Mild sedation (particularly in cats)
注意事項與禁忌
- No labeled contraindications, but use with caution if the patient is already receiving ethanol therapy.
- > **Dilution Required**: Concentrated drug must be diluted as directed before intravenous administration to prevent severe vein irritation. * **Timing**: Efficacy drops significantly if given after 8 hours in dogs, or after 3 hours in cats. If azotemia is present, prognosis is poor. * **Supportive Care**: Fomepizole must be used alongside aggressive fluid therapy and correction of acid-base/electrolyte imbalances. * **Decontamination**: If the patient presents within 1-2 hours of ingestion, consider inducing emesis or performing gastric lavage with activated charcoal to minimize absorption. * **Pregnancy**: FDA Category C. Benefits generally outweigh risks in life-threatening toxicity.
藥物相互作用
- Ethanol: Fomepizole inhibits alcohol dehydrogenase; ethanol metabolism is reduced significantly and alcohol poisoning (CNS depression, coma, death) can occur. Concurrent use is generally not recommended. If used together, mandatory monitoring of ethanol blood levels is required.
常見問題
Fomepizole用於寵物有甚麼用途？
> **Medical Emergency**: Antifreeze (ethylene glycol) poisoning is a life-threatening emergency. Time is absolutely critical. * **Rapid Action Needed**: Dogs treated within 8 hours of ingestion have a much better chance of survival. Cats are extremely sensitive and must be treated within **3 hours** of ingestion. * **Intensive Care**: Treatment requires hospitalization in an intensive care setting. Your pet will need IV fluids, frequent blood tests, and close monitoring. * **Cost**: The antidote (fomepizole) and the associated intensive care can be quite expensive, especially for large dogs. You will need to make an informed decision rapidly to give your pet the best chance of survival.
Fomepizole對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。