Dimethyl Sulfoxide (DMSO)
別名: Domoso, Kemsol, Rheumabene, Rimso, Synotic, Rimso-50, DMSO
**Important Safety Guidelines for Pet Owners:** * **Use Only Prescribed Medical Grade:** Never use industrial or non-medical grades of DMSO (often found in hardware stores), as they may contain harmful impurities that the DMSO will carry directly into your pet's bloodstream. * **Protect Yourself:** **Always wear rubber gloves** when applying this medication. If it gets on your skin, you will absorb it and likely taste garlic in your mouth shortly after! * **Application:** Apply only to clean, dry skin using clean or sterile cotton. Do not mix with any other ointments, flea products, or chemicals without your veterinarian's explicit approval, as DMSO will pull those chemicals into the body. * **Odor:** It is completely normal for your pet to develop a strong garlic or oyster-like breath odor while on this medication. This will resolve once the medication is stopped. * **Storage & Handling:** Use in a well-ventilated area. Avoid inhaling it or getting it in your eyes. It may damage certain fabrics. Keep the lid tightly closed when not in use, as it pulls moisture from the air and will dilute itself. Keep out of reach of children.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Acute swelling due to trauma
- Adjunctive treatment with surgical colics
- Acute rhabdomyolysis
- Adjunctive treatment for laminitis
- Acute swelling due to trauma
- Calcinosis cutis
- Persistent cases of hemorrhagic cystitis (secondary to cyclophosphamide tx)
- Extravasation of cytotoxic vesicant (e.g., doxorubicin)
- Haemorrhagic cystitis induced by cyclophosphamide
- Canine calcinosis cutis
- Renal amyloidosis
- Extravasation of cytotoxic vesicant
給藥方式
可能的副作用
- Local 'burning', erythema, vesiculation, and dry skin (topical)
- Garlic or oyster-like breath odor
- Lenticular changes (myopia) with chronic high doses
- Hemolysis and hemoglobinuria (IV in horses, especially at >10% concentration or rapid administration)
- Diarrhea, muscle tremors, and colic (IV in horses)
- Rare hepatotoxicity and renal toxicity
注意事項與禁忌
- Mastocytomas (due to mast cell degranulation)
- Dehydration or shock (diuretic and vasodilatory effects may exacerbate)
- Pregnancy (teratogenic at high doses in some species; use with extreme caution)
- > **Handling Warning:** Always wear rubber gloves when applying topically. Apply with clean or sterile cotton to clean, dry skin to prevent carrying harmful impurities or environmental toxins into the systemic circulation. * **Masking Pathology:** Potent anti-inflammatory and analgesic activity may mask existing pathology. * **IV Administration:** In horses, administer IV slowly and at concentrations of 10% (maximum 20%) to minimize hemolysis and hemoglobinuria. * **Odor:** Owners should be warned about the strong garlic/oyster breath odor that develops shortly after administration, regardless of route.
藥物相互作用
- Organophosphates / Cholinesterase Inhibitors: Avoid concurrent use due to DMSO's anticholinesterase activity.
- Mercury salts: Can cause fatal mercury intoxication if mixed and applied topically.
- Alcohol: DMSO inhibits alcohol dehydrogenase and may prolong the effects of alcohol.
- Insulin: May be potentiated by DMSO.
- Corticosteroids: May be potentiated by DMSO.
- Atropine: May be potentiated by DMSO.
- Topical toxins or other topical medications: Profound enhancement of systemic absorption of the co-administered substance, potentially leading to systemic toxicity.
- Dexrazoxane: DMSO may decrease the activity and efficacy of dexrazoxane; concurrent use should be discouraged.
常見問題
Dimethyl Sulfoxide (DMSO)用於寵物有甚麼用途？
**Important Safety Guidelines for Pet Owners:** * **Use Only Prescribed Medical Grade:** Never use industrial or non-medical grades of DMSO (often found in hardware stores), as they may contain harmful impurities that the DMSO will carry directly into your pet's bloodstream. * **Protect Yourself:** **Always wear rubber gloves** when applying this medication. If it gets on your skin, you will absorb it and likely taste garlic in your mouth shortly after! * **Application:** Apply only to clean, dry skin using clean or sterile cotton. Do not mix with any other ointments, flea products, or chemicals without your veterinarian's explicit approval, as DMSO will pull those chemicals into the body. * **Odor:** It is completely normal for your pet to develop a strong garlic or oyster-like breath odor while on this medication. This will resolve once the medication is stopped. * **Storage & Handling:** Use in a well-ventilated area. Avoid inhaling it or getting it in your eyes. It may damage certain fabrics. Keep the lid tightly closed when not in use, as it pulls moisture from the air and will dilute itself. Keep out of reach of children.
Dimethyl Sulfoxide (DMSO)對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。