Ampicillin and Sulbactam
別名: Unasyn
* **Hospital Use Only**: Because this medication must be given by injection (IV or IM) and requires frequent dosing (every 6 to 8 hours), it is best administered to hospitalized patients. * **Purpose**: It is a potent antibiotic combination used to treat severe or resistant bacterial infections, often utilized when oral medications cannot be tolerated. * **Safety**: Generally very safe, but let your veterinary team know if your pet has ever had an allergic reaction to penicillin-type drugs.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- For respiratory infections using ampicillin/sulbactam (Unasyn®)
- As adjunctive treatment of serious bite wounds
- For intra-abdominal infections
- For respiratory infections
- For respiratory infections
- As adjunctive treatment of serious bite wounds
- For intra-abdominal infections
給藥方式
可能的副作用
- Pain at intramuscular injection sites
- Thrombophlebitis (with intravenous injection)
- Hypersensitivity reactions (including severe anaphylaxis, particularly after IV administration)
- Neurotoxicity (e.g., ataxia in dogs) at high doses or prolonged use
- Elevated liver enzymes
- Tachypnea, dyspnea, edema, and tachycardia (reported in dogs)
注意事項與禁忌
- Patients with a history of severe hypersensitivity (e.g., anaphylaxis) to penicillins
- Use cautiously in patients with documented hypersensitivity to other beta-lactam antibiotics (e.g., cephalosporins, cefamycins, carbapenems) due to potential cross-reactivity. Patients with severe renal dysfunction may require increased intervals between doses. Safe use during pregnancy has not been firmly established (FDA Category B; Papich Class A), use only when potential benefits outweigh risks.
藥物相互作用
- Aminoglycosides (amikacin, gentamicin, tobramycin): In vitro inactivation if mixed together; synergistic in vivo, but penicillins can inactivate aminoglycosides in patients with renal failure or when used in massive dosages. Amikacin is the most resistant to this inactivation.
- Bacteriostatic antimicrobials (chloramphenicol, macrolides, tetracyclines, sulfonamides): Potential in vitro antagonism between beta-lactam antibiotics and bacteriostatic antibiotics; clinical importance is unclear.
- Probenecid: Reduces the renal tubular secretion of both ampicillin and sulbactam, maintaining higher systemic levels for a longer period.
常見問題
Ampicillin and Sulbactam用於寵物有甚麼用途？
* **Hospital Use Only**: Because this medication must be given by injection (IV or IM) and requires frequent dosing (every 6 to 8 hours), it is best administered to hospitalized patients. * **Purpose**: It is a potent antibiotic combination used to treat severe or resistant bacterial infections, often utilized when oral medications cannot be tolerated. * **Safety**: Generally very safe, but let your veterinary team know if your pet has ever had an allergic reaction to penicillin-type drugs.
Ampicillin and Sulbactam對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。