톨라졸린

용도

• For reversal of xylazine effects
• For reversal of xylazine effects
• For reversal of xylazine effects
• For reversal of xylazine effects
• For reversal of xylazine effects
• For reversal of xylazine effects
• For reversal of xylazine effects (Emergency)
• For reversal of xylazine effects
• As a reversal agent for alpha2-adrenergic agonists (e.g., xylazine, detomidine, etc.)
• For reversal of xylazine effects

투여 방법

가능한 부작용

• Transient tachycardia
• Peripheral vasodilation (sweating, injected mucous membranes of gingiva and conjunctiva)
• Hyperalgesia of the lips (licking, flipping of lips)
• Piloerection
• Clear lacrimal and nasal discharge
• Muscle fasciculations
• Apprehensiveness and anxiety
• Gastrointestinal hypermotility (flatulence, diarrhea, mild colic)

주의사항 및 금기

• Horses exhibiting signs of stress, debilitation, or shock
• Cardiac disease or coronary artery disease
• Sympathetic blockage
• Hypovolemia
• Cerebrovascular disease
• Known hypersensitivity to the drug
• Foals (relative contraindication; adverse reactions and fatalities reported)
• > **WARNING: Rapid IV Administration** > Acute death and cardiac asystole have been reported after rapid IV administration of tolazoline at high dosages, particularly in camelids and cattle. Always administer IV slowly (e.g., 1 mL/second) or consider the IM route. * **High Concentration Risk**: The veterinary formulation is highly concentrated (100 mg/mL), making accurate dosing difficult in small animals (dogs/cats). Yohimbine or atipamezole are generally safer alternatives for small animals. * **Human Safety**: Humans with coronary artery or cerebrovascular disease should use extra caution when handling this agent.

약물 상호작용

• Alcohol: Accumulation of acetaldehyde can occur if tolazoline and alcohol are given simultaneously.
• Epinephrine: If large doses of tolazoline are given with epinephrine, a paradoxical drop in blood pressure can occur followed by a precipitous increase in blood pressure.
• Norepinephrine: If large doses of tolazoline are given with norepinephrine, a paradoxical drop in blood pressure can occur followed by a precipitous increase in blood pressure.

자주 묻는 질문