티카실린 / 클라불란산

용도

• Sepsis
• Pseudomonas sepsis/bacteremia
• Resistant Pseudomonas infections
• Susceptible infections
• Serious systemic infections
• Pseudomonas otitis (adjunct)
• Susceptible infections
• Neonatal septicemia (Foals)
• Susceptible infections (Foals)
• Intrauterine infusion
• Sepsis
• Susceptible infections
• Pseudomonas sepsis/bacteremia
• Adjunctive treatment of Pseudomonas otitis

투여 방법

가능한 부작용

• Hypersensitivity reactions (allergic reactions)
• Platelet dysfunction and bleeding (especially at high doses or with renal impairment)
• CNS effects including headache, giddiness, hallucinations, and seizures (at high doses)
• Pain at intramuscular (IM) injection sites
• Phlebitis or local vein irritation (IV administration)
• Antibiotic-associated diarrhea or colitis
• Nausea
• Diarrhoea
• Skin rashes

주의사항 및 금기

• Documented hypersensitivity to penicillins or other beta-lactam antibiotics
• Known hypersensitivity to penicillins or other beta-lactam antibiotics
• Dosage adjustments should be made in patients with significantly impaired renal function. Patients receiving very high dosages or those with renal impairment are more prone to developing platelet function abnormalities (bleeding) or CNS toxicity. IV administration should be given slowly (over at least 30 minutes) using dilute concentrations to avoid vein irritation.

약물 상호작용

• Aminoglycosides (e.g., amikacin, gentamicin, tobramycin): In vitro synergy against certain bacteria; however, penicillins can chemically inactivate aminoglycosides in vitro and in vivo (especially in renal failure or at massive doses). Do not mix in the same syringe or IV line.
• Probenecid: Reduces renal tubular secretion of ticarcillin, maintaining higher systemic levels for a longer duration (does not affect clavulanate elimination).
• Warfarin: Increased risk of bleeding due to potential ticarcillin-induced platelet dysfunction; use with caution.
• Heparin: Increased risk of bleeding due to potential ticarcillin-induced platelet dysfunction; use with caution.
• Aminoglycosides (e.g., gentamicin): Mutual inactivation if mixed in the same syringe. However, there is significant synergism in vivo against Pseudomonas when administered separately.

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