Ticarcillin / Clavulanate
別名: Timentin, Claventin
> **Note:** This medication is primarily used as an injectable drug in a hospital setting for severe, life-threatening infections. * **Compounded Ear Drops:** If your veterinarian has prescribed this as a compounded ear drop for stubborn *Pseudomonas* infections, keep the aliquots (syringes/vials) **frozen** until needed. Thaw individual doses just before use as directed. * **Side Effects:** Watch for signs of an allergic reaction (facial swelling, hives, difficulty breathing) or severe diarrhea, and contact your veterinarian immediately if these occur. * **Bleeding Risk:** Rarely, this drug can affect blood clotting. Report any unusual bruising or bleeding.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Sepsis
- Pseudomonas sepsis/bacteremia
- Resistant Pseudomonas infections
- Susceptible infections
- Serious systemic infections
- Pseudomonas otitis (adjunct)
- Susceptible infections
- Neonatal septicemia (Foals)
- Susceptible infections (Foals)
- Intrauterine infusion
- Sepsis
- Susceptible infections
- Pseudomonas sepsis/bacteremia
- Adjunctive treatment of Pseudomonas otitis
給藥方式
可能的副作用
- Hypersensitivity reactions (allergic reactions)
- Platelet dysfunction and bleeding (especially at high doses or with renal impairment)
- CNS effects including headache, giddiness, hallucinations, and seizures (at high doses)
- Pain at intramuscular (IM) injection sites
- Phlebitis or local vein irritation (IV administration)
- Antibiotic-associated diarrhea or colitis
- Nausea
- Diarrhoea
- Skin rashes
注意事項與禁忌
- Documented hypersensitivity to penicillins or other beta-lactam antibiotics
- Known hypersensitivity to penicillins or other beta-lactam antibiotics
- Dosage adjustments should be made in patients with significantly impaired renal function. Patients receiving very high dosages or those with renal impairment are more prone to developing platelet function abnormalities (bleeding) or CNS toxicity. IV administration should be given slowly (over at least 30 minutes) using dilute concentrations to avoid vein irritation.
藥物相互作用
- Aminoglycosides (e.g., amikacin, gentamicin, tobramycin): In vitro synergy against certain bacteria; however, penicillins can chemically inactivate aminoglycosides in vitro and in vivo (especially in renal failure or at massive doses). Do not mix in the same syringe or IV line.
- Probenecid: Reduces renal tubular secretion of ticarcillin, maintaining higher systemic levels for a longer duration (does not affect clavulanate elimination).
- Warfarin: Increased risk of bleeding due to potential ticarcillin-induced platelet dysfunction; use with caution.
- Heparin: Increased risk of bleeding due to potential ticarcillin-induced platelet dysfunction; use with caution.
- Aminoglycosides (e.g., gentamicin): Mutual inactivation if mixed in the same syringe. However, there is significant synergism in vivo against Pseudomonas when administered separately.
常見問題
Ticarcillin / Clavulanate用於寵物有甚麼用途？
> **Note:** This medication is primarily used as an injectable drug in a hospital setting for severe, life-threatening infections. * **Compounded Ear Drops:** If your veterinarian has prescribed this as a compounded ear drop for stubborn *Pseudomonas* infections, keep the aliquots (syringes/vials) **frozen** until needed. Thaw individual doses just before use as directed. * **Side Effects:** Watch for signs of an allergic reaction (facial swelling, hives, difficulty breathing) or severe diarrhea, and contact your veterinarian immediately if these occur. * **Bleeding Risk:** Rarely, this drug can affect blood clotting. Report any unusual bruising or bleeding.
Ticarcillin / Clavulanate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。