설파디메톡신/오르메토프림

용도

• Susceptible infections
• Susceptible infections (skin and soft tissue)

투여 방법

가능한 부작용

• Keratoconjunctivitis sicca (KCS/dry eye) - potentially irreversible
• Acute neutrophilic hepatitis with icterus
• Vomiting
• Anorexia
• Diarrhea
• Fever
• Hemolytic anemia
• Urticaria
• Polyarthritis
• Facial swelling
• Polydipsia and polyuria
• Cholestasis
• Hypersensitivity reactions (Type I anaphylaxis or Type III serum sickness)
• Hypothyroidism (with extended use)

주의사항 및 금기

• Hypersensitivity to sulfonamides, thiazides, or sulfonylurea agents
• Severe renal or hepatic impairment
• Marked liver parenchymal damage
• Blood dyscrasias
• Doberman Pinschers (highly susceptible to sulfonamide-induced poly-systemic immune complex disease)
• Use with caution in patients with pre-existing hepatic or thyroid disease, diminished renal function, urinary obstruction, or urolithiasis. Hypersensitivity reactions appear more common in large breed dogs. Potentially teratogenic (cleft palate reported in lab animals with TMP/sulfa); weigh risk versus benefit in pregnant animals.

약물 상호작용

• Various (Refer to Trimethoprim/Sulfa): Specific interactions are not explicitly noted for this combination, but it is expected to share the interaction profile of trimethoprim/sulfa (e.g., potential antagonism with cyclosporine, increased risk of bleeding with anticoagulants).

자주 묻는 질문