피조스티그민

용도

• For reversal of tall larkspur (Delphinium barbeya) poisoning
• Provocative test in diagnosing cataplexy or narcolepsy
• Provocative test in diagnosing cataplexy or narcolepsy
• To temporarily reverse the CNS effects of ivermectin toxicosis in support of the diagnosis
• To temporarily reverse the CNS effects of ivermectin toxicosis in support of the diagnosis
• Provocative test for narcolepsy/cataplexy

투여 방법

가능한 부작용

• Miosis
• Bronchial constriction
• Hypersalivation
• Muscle weakness
• Sweating (in species with sweat glands)
• Seizures
• Bradycardia
• Tachycardia
• Asystole
• Nausea
• Vomiting
• Diarrhea
• Depolarizing neuromuscular block
• Pulmonary edema
• Respiratory paralysis

주의사항 및 금기

• Prior hypersensitivity reactions to physostigmine or sulfites
• Bronchoconstrictive disease (asthma)
• Gangrene
• Diabetes mellitus
• Cardiovascular disease
• Mechanical obstruction of the GI or urinary tract
• Any vagotonic state
• Concurrent use of choline esters or depolarizing neuromuscular blocking agents
• > **WARNING:** Toxic effects from this drug can be serious and life-threatening. Must be administered with direct patient supervision. * **Cholinergic Crisis Risk:** Increased risk when used in the absence of anticholinergic toxicity or to treat tricyclic/tetracyclic antidepressant overdoses. * **Administration Rate:** Rapid IV administration increases the potential for bradycardia, hypersalivation, or seizures. Must be given slowly. * **Antidote Availability:** Atropine must be readily available when administering physostigmine. * **Neonatal Toxicity:** The injection contains benzyl alcohol, which may be toxic to neonatal animals. * **Pregnancy:** Weigh potential risks versus benefits. Teratogenic effects have been observed in mice.

약물 상호작용

• Choline esters (bethanechol, carbachol, methacholine): May cause additive adverse cholinergic effects.
• Organophosphates: May cause additive adverse cholinergic effects.
• Succinylcholine: High doses of physostigmine may cause muscle fasciculations or depolarization block, which may be additive to the effects of succinylcholine-like neuromuscular blockers.

자주 묻는 질문