Physostigmine
別名: Antilirium, Anticholium
This medication is strictly for use in a clinical setting. * **Direct Supervision:** It must be administered in a veterinary hospital where direct veterinary supervision and emergency monitoring are available. * **Not for Home Use:** Due to the risk of severe and potentially life-threatening side effects, this drug is never dispensed for owners to administer at home.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- For reversal of tall larkspur (Delphinium barbeya) poisoning
- Provocative test in diagnosing cataplexy or narcolepsy
- Provocative test in diagnosing cataplexy or narcolepsy
- To temporarily reverse the CNS effects of ivermectin toxicosis in support of the diagnosis
- To temporarily reverse the CNS effects of ivermectin toxicosis in support of the diagnosis
- Provocative test for narcolepsy/cataplexy
給藥方式
可能的副作用
- Miosis
- Bronchial constriction
- Hypersalivation
- Muscle weakness
- Sweating (in species with sweat glands)
- Seizures
- Bradycardia
- Tachycardia
- Asystole
- Nausea
- Vomiting
- Diarrhea
- Depolarizing neuromuscular block
- Pulmonary edema
- Respiratory paralysis
注意事項與禁忌
- Prior hypersensitivity reactions to physostigmine or sulfites
- Bronchoconstrictive disease (asthma)
- Gangrene
- Diabetes mellitus
- Cardiovascular disease
- Mechanical obstruction of the GI or urinary tract
- Any vagotonic state
- Concurrent use of choline esters or depolarizing neuromuscular blocking agents
- > **WARNING:** Toxic effects from this drug can be serious and life-threatening. Must be administered with direct patient supervision. * **Cholinergic Crisis Risk:** Increased risk when used in the absence of anticholinergic toxicity or to treat tricyclic/tetracyclic antidepressant overdoses. * **Administration Rate:** Rapid IV administration increases the potential for bradycardia, hypersalivation, or seizures. Must be given slowly. * **Antidote Availability:** Atropine must be readily available when administering physostigmine. * **Neonatal Toxicity:** The injection contains benzyl alcohol, which may be toxic to neonatal animals. * **Pregnancy:** Weigh potential risks versus benefits. Teratogenic effects have been observed in mice.
藥物相互作用
- Choline esters (bethanechol, carbachol, methacholine): May cause additive adverse cholinergic effects.
- Organophosphates: May cause additive adverse cholinergic effects.
- Succinylcholine: High doses of physostigmine may cause muscle fasciculations or depolarization block, which may be additive to the effects of succinylcholine-like neuromuscular blockers.
常見問題
Physostigmine用於寵物有甚麼用途？
This medication is strictly for use in a clinical setting. * **Direct Supervision:** It must be administered in a veterinary hospital where direct veterinary supervision and emergency monitoring are available. * **Not for Home Use:** Due to the risk of severe and potentially life-threatening side effects, this drug is never dispensed for owners to administer at home.
Physostigmine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。