毒扁豆鹼
別名: Antilirium, Anticholium
藥物類別: Cholinesterase Inhibitor
本藥物僅限於臨床環境中使用。 * **直接監督：** 必須在有獸醫師直接監督及具備急救監測設備的獸醫院內給藥。 * **不可居家使用：** 由於具有引發嚴重且可能危及生命副作用的風險，本藥物絕對不會交由飼主帶回家自行投藥。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- For reversal of tall larkspur (Delphinium barbeya) poisoning
- Provocative test in diagnosing cataplexy or narcolepsy
- Provocative test in diagnosing cataplexy or narcolepsy
- To temporarily reverse the CNS effects of ivermectin toxicosis in support of the diagnosis
- To temporarily reverse the CNS effects of ivermectin toxicosis in support of the diagnosis
- Provocative test for narcolepsy/cataplexy
給藥方式
IVIMSC
可能的副作用
- Miosis
- Bronchial constriction
- Hypersalivation
- Muscle weakness
- Sweating (in species with sweat glands)
- Seizures
- Bradycardia
- Tachycardia
- Asystole
- Nausea
- Vomiting
- Diarrhea
- Depolarizing neuromuscular block
- Pulmonary edema
- Respiratory paralysis
注意事項與禁忌
- Prior hypersensitivity reactions to physostigmine or sulfites
- Bronchoconstrictive disease (asthma)
- Gangrene
- Diabetes mellitus
- Cardiovascular disease
- Mechanical obstruction of the GI or urinary tract
- Any vagotonic state
- Concurrent use of choline esters or depolarizing neuromuscular blocking agents
- > **WARNING:** Toxic effects from this drug can be serious and life-threatening. Must be administered with direct patient supervision. * **Cholinergic Crisis Risk:** Increased risk when used in the absence of anticholinergic toxicity or to treat tricyclic/tetracyclic antidepressant overdoses. * **Administration Rate:** Rapid IV administration increases the potential for bradycardia, hypersalivation, or seizures. Must be given slowly. * **Antidote Availability:** Atropine must be readily available when administering physostigmine. * **Neonatal Toxicity:** The injection contains benzyl alcohol, which may be toxic to neonatal animals. * **Pregnancy:** Weigh potential risks versus benefits. Teratogenic effects have been observed in mice.
藥物相互作用
- Choline esters (bethanechol, carbachol, methacholine): May cause additive adverse cholinergic effects.
- Organophosphates: May cause additive adverse cholinergic effects.
- Succinylcholine: High doses of physostigmine may cause muscle fasciculations or depolarization block, which may be additive to the effects of succinylcholine-like neuromuscular blockers.
常見問題
毒扁豆鹼用於寵物有什麼用途？
本藥物僅限於臨床環境中使用。 • 直接監督： 必須在有獸醫師直接監督及具備急救監測設備的獸醫院內給藥。 • 不可居家使用： 由於具有引發嚴重且可能危及生命副作用的風險，本藥物絕對不會交由飼主帶回家自行投藥。
毒扁豆鹼對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。