밀베마이신 옥심

용도

• Prevention of heartworm; treat adult hookworm and adult roundworms
• Heartworm prophylaxis, control of adult hookworms, roundworms, and whipworms
• Microfilaricide chemotherapy (in adulticide-pretreated dogs)
• Treatment of generalized demodicosis
• Treatment of cheyletiellosis
• Treatment of scabies
• Chronic rhinitis caused by Pneumonyssus caninum
• Nematodes

투여 방법

가능한 부작용

• Transient shock-like syndrome (in microfilaremic animals)
• Ataxia
• Trembling
• Mydriasis
• Hypersalivation
• Lethargy
• Pyrexia
• Seizures
• Coma

주의사항 및 금기

• Puppies less than 4 weeks of age or less than 2 lbs
• Kittens less than 6 weeks of age or less than 1.5 lbs
• Because some dogs with a high number of circulating microfilaria will develop a transient, shock-like syndrome after receiving milbemycin, testing for preexisting heartworm infections is recommended before use. If using at doses greater than labeled in breeds susceptible to the ABCB1 genetic mutation, genetic testing is recommended before initiating therapy. Safety in breeding, pregnant, and lactating queens and breeding toms has not been established.

약물 상호작용

• Benzodiazepines: Effects may be potentiated by milbemycin; concurrent use is not advised in humans and warrants caution in animals.
• P-glycoprotein inhibitors (Amiodarone, Ketoconazole, Cyclosporine, Diltiazem, Erythromycin, Clarithromycin, Quinidine, Spironolactone, Tamoxifen, Verapamil): May inhibit the efflux pump at the blood-brain barrier, increasing the risk of milbemycin neurotoxicity, particularly in dogs at risk for the ABCB1-1 (MDR1) mutation.

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