글리코피로늄 / 글리코피롤레이트

용도

투여 방법

가능한 부작용

• Tachycardia
• Ventricular arrhythmias
• Thickened, sticky airway secretions
• Paradoxical bradycardia (at very low IV doses)

주의사항 및 금기

• Concurrent use with alpha-2 adrenergic agonists is not recommended
• - **Paradoxical Bradycardia:** Administration of very low doses of glycopyrronium IV can cause exacerbation of bradyarrhythmias due to a vagal stimulatory effect. Giving another dose IV will usually cause an increase in heart rate. - **Airway Secretions:** Decreases the water content of oral and bronchial secretions, making them more sticky. - **Opioid Bradycardia:** It is better to monitor heart rate and give glycopyrronium to manage a low heart rate only if necessary, rather than as a routine premedication.

약물 상호작용

• Barbiturates (alkaline drugs): In vitro incompatibility; a precipitate may form if mixed together
• Sympathomimetics: Antimuscarinics may enhance the actions of sympathomimetics
• Thiazide diuretics: Antimuscarinics may enhance the actions of thiazide diuretics
• Antihistamines: May enhance the anticholinergic activity of glycopyrronium
• Pethidine: May enhance the anticholinergic activity of glycopyrronium
• Benzodiazepines: May enhance the anticholinergic activity of glycopyrronium
• Phenothiazines: May enhance the anticholinergic activity of glycopyrronium
• Alpha-2 adrenergic agonists: Combining glycopyrronium and alpha-2 adrenergic agonists is not recommended due to conflicting cardiovascular effects

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