에탄올

용도

• Ethylene glycol poisoning
• Ethylene glycol poisoning
• Ethylene glycol toxicity
• Ethylene glycol toxicity (CRI method)
• Ethylene glycol toxicity (mild cases)
• Ethylene glycol poisoning
• Ethylene glycol poisoning
• Ethylene glycol toxicity

투여 방법

가능한 부작용

• CNS depression
• Respiratory depression
• Diuresis
• Hypocalcemia
• Metabolic acidosis
• Pulmonary edema
• Injection site pain and infection
• Phlebitis
• Extravasation injury
• Bronchoconstriction and irritation (when aerosolized)

주의사항 및 금기

• Concurrent use with fomepizole (usually contraindicated)
• Because ethylene glycol and methanol intoxications are life-threatening, there are no absolute contraindications to ethanol's use for these indications. Monitor fluid and electrolyte therapy requirements closely, as both the toxin and ethanol can cause diuresis. Watch for and avoid extravasation. Use during pregnancy only when necessary (FDA Category C). Ethanol may cause false positive reports on ethylene glycol screening tests.

약물 상호작용

• Bromocriptine: Alcohol may increase the severity of side effects seen with bromocriptine
• Activated Charcoal: Will inhibit absorption of orally administered ethanol; do not use if administering ethanol orally
• CNS Depressant Drugs (barbiturates, benzodiazepines, phenothiazines): Alcohol may cause additive CNS depression
• Fomepizole (4-MP): Inhibits alcohol dehydrogenase; ethanol metabolism is reduced significantly and alcohol poisoning (CNS depression, coma, death) can occur. Use together is generally not recommended.
• Insulin and antidiabetic drugs: Alcohol may affect glucose metabolism and the actions of insulin or oral antidiabetic agents
• Chlorpropamide, furazolidone, metronidazole: A disulfiram reaction (increased acetaldehyde with tachycardia, vomiting, weakness) may occur
• Fomepizole: Increases risk of severe alcohol toxicity; concurrent use should be avoided.

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