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용도

• Anemia of chronic kidney disease
• Anemia of chronic kidney disease

투여 방법

가능한 부작용

• Anti-rHuEPO antibody formation leading to pure red blood cell aplasia (PRCA)
• Hypertension
• Seizures
• Iron deficiency (due to rapid RBC production depleting iron stores)

주의사항 및 금기

• Patients with documented anti-rHuEPO antibodies
• Uncontrolled hypertension
• Hypersensitivity to darbepoetin or excipients in the formulation
• Use with extreme caution in patients with pre-existing hypertension; blood pressure must be monitored. Monitor closely for the development of anti-rHuEPO antibodies, which is diagnosed by a sudden, severe drop in PCV, a high myeloid:erythroid ratio on bone marrow cytology, and the exclusion of other causes of anemia. Ensure adequate iron stores prior to and during therapy, as rapid erythropoiesis can quickly deplete iron.

약물 상호작용

• Androgens: May increase the sensitivity of erythroid progenitors (interaction has been used for therapeutic effect with epoetin)
• Desmopressin: Can decrease bleeding times when used concurrently with erythropoietin agents

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