ダルベポエチンアルファ

使用用途

• Anemia of chronic kidney disease
• Anemia of chronic kidney disease

投与方法

考えられる副作用

• Anti-rHuEPO antibody formation leading to pure red blood cell aplasia (PRCA)
• Hypertension
• Seizures
• Iron deficiency (due to rapid RBC production depleting iron stores)

注意事項と禁忌

• Patients with documented anti-rHuEPO antibodies
• Uncontrolled hypertension
• Hypersensitivity to darbepoetin or excipients in the formulation
• Use with extreme caution in patients with pre-existing hypertension; blood pressure must be monitored. Monitor closely for the development of anti-rHuEPO antibodies, which is diagnosed by a sudden, severe drop in PCV, a high myeloid:erythroid ratio on bone marrow cytology, and the exclusion of other causes of anemia. Ensure adequate iron stores prior to and during therapy, as rapid erythropoiesis can quickly deplete iron.

薬物相互作用

• Androgens: May increase the sensitivity of erythroid progenitors (interaction has been used for therapeutic effect with epoetin)
• Desmopressin: Can decrease bleeding times when used concurrently with erythropoietin agents

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