ワルファリンナトリウム
別称: Coumadin, Jantoven, Panwarfin
薬の分類: Anticoagulant - Coumarin Derivative
獣医師の指示通りに正確に投薬することが非常に重要です。自己判断で用量を変更しないでください。出血の兆候（歯茎の蒼白、異常な内出血、鼻血、血尿、黒色便や血便、突然の虚弱など）が見られた場合は、直ちに獣医師に連絡してください。外傷による重篤な出血を防ぐため、投薬中のペット（特に猫）は室内飼育とし、激しい運動は避けてください。獣医師の許可なく新しい薬やサプリメントを与えないでください。
用量はペットの状態に応じて獣医師が決定します。獣医師の指導なしに人用医薬品や他のペットの処方薬を与えないでください。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
使用用途
- Adjunctive maintenance therapy for venous thrombosis with or without pulmonary thromboembolism (PTE)
- Maintenance therapy for feline arterial thromboembolism
- Long-term thromboprophylaxis
- Adjunctive therapy of thromboembolism
- Cardiogenic arterial thromboembolism
- Adjunctive treatment of laminitis
- Anticoagulant
- Adjunctive maintenance therapy for venous thrombosis with or without pulmonary thromboembolism (PTE)
- Adjunctive therapy of thromboemboli
- Prophylactic use in patients with glomerular disease and severe proteinuria
投与方法
POIV
考えられる副作用
- Dose-related hemorrhage (primary adverse effect)
- Anemia
- Thrombocytopenia
- Weakness
- Hematomas and ecchymoses
- Epistaxis (nosebleeds)
- Hematemesis (vomiting blood)
- Hematuria (blood in urine)
- Melena (dark, tarry stools)
- Hematochezia (fresh blood in stools)
- Hemarthrosis (bleeding into joints)
- Hemothorax
- Intracranial hemorrhage
- Pericardial hemorrhage
- Death
注意事項と禁忌
- Preexistent hemorrhagic tendencies or diseases
- Patients undergoing or contemplating eye or CNS surgery
- Major regional lumbar block anesthesia
- Surgery of large, open surfaces
- Active bleeding from the GI, respiratory, or GU tract
- Aneurysm
- Acute nephritis
- Cerebrovascular hemorrhage
- Blood dyscrasias
- Uncontrolled or malignant hypertension
- Hepatic insufficiency
- Pericardial effusion
- Pregnancy (Teratogenic - FDA Category X / Papich Class D)
- Visceral carcinomas
- > **Strict Monitoring Required:** Warfarin has a narrow therapeutic index. Frequent monitoring of coagulation status (PT/INR) is mandatory to prevent fatal hemorrhage. * **Teratogenicity:** Warfarin is embryotoxic and causes congenital malformations. It is strictly contraindicated in pregnancy. Low-dose heparin is preferred if anticoagulation is required during pregnancy. * **Nursing:** Use with caution in nursing patients; prolonged prothrombin times have been reported in some breast-fed human infants. * **Dietary Changes:** Sudden changes in diet (especially foods high in Vitamin K) can alter the efficacy of warfarin. * **Laboratory Interference:** May cause falsely decreased theophylline values if using the Schack and Waxler ultraviolet method.
薬物相互作用
- Acetaminophen, NSAIDs, Salicylates: May increase anticoagulant response (via protein displacement or platelet inhibition); increases bleeding risk.
- Fluoroquinolones, Macrolides (Azithromycin, Erythromycin), Chloramphenicol, Sulfonamides, Co-trimoxazole: May increase anticoagulant response (often via inhibition of hepatic metabolism).
- Cimetidine, Cisapride, Fluoxetine, Metronidazole, Sertraline: May increase anticoagulant response.
- Amiodarone, Allopurinol, Danazol, Diazoxide, Ethacrynic acid, Pentoxifylline, Propylthiouracil, Quinidine, Zafirlukast: May increase anticoagulant response.
- Anabolic Steroids, Thyroid Medications: May increase anticoagulant response.
- Heparin: Increases anticoagulant response; often used concurrently during the initial overlap phase but requires careful monitoring.
- Barbiturates (e.g., Phenobarbital), Rifampin, Griseofulvin: May decrease anticoagulant response (via induction of hepatic metabolizing enzymes).
- Corticosteroids, Estrogens, Mercaptopurine, Spironolactone, Sucralfate: May decrease anticoagulant response.
- Vitamin K: Directly antagonizes warfarin, decreasing its anticoagulant response (used as an antidote for overdose).
よくある質問
ワルファリンナトリウムはペットにどう使われていますか？
獣医師の指示通りに正確に投薬することが非常に重要です。自己判断で用量を変更しないでください。出血の兆候（歯茎の蒼白、異常な内出血、鼻血、血尿、黒色便や血便、突然の虚弱など）が見られた場合は、直ちに獣医師に連絡してください。外傷による重篤な出血を防ぐため、投薬中のペット（特に猫）は室内飼育とし、激しい運動は避けてください。獣医師の許可なく新しい薬やサプリメントを与えないでください。
ワルファリンナトリウムはうちのペットに安全ですか？
用量はペットの状態に応じて獣医師が決定します。獣医師の指導なしに人用医薬品や他のペットの処方薬を与えないでください。
この記事は一般的な健康教育を目的としており、専門的な獣医学的アドバイスの代わりにはなりません。ペットが調子悪い場合は、獣医師にご相談ください。