Warfarin Sodium
別名: Coumadin, Jantoven, Panwarfin
> **Critical Warning:** Warfarin is a potent blood thinner. Strict adherence to the prescribed dosing schedule is absolutely essential. Do not skip doses or give extra doses without consulting your veterinarian. * **Watch for Bleeding:** Immediately report any signs of bleeding to your veterinarian. This includes pale gums, unusual bruising, nosebleeds, blood in the urine or stool (which may look black and tarry), vomiting blood, coughing up blood, or sudden weakness/lethargy. * **Prevent Trauma:** Keep pets (especially cats) indoors and restrict rough play to minimize the risk of traumatic injury, which could lead to severe bleeding. * **Medication Interactions:** Do not give your pet any new medications, supplements, or over-the-counter drugs (especially aspirin or other pain relievers) without checking with your veterinarian, as many drugs interact dangerously with warfarin. * **Diet:** Keep your pet's diet consistent, as sudden changes in food (especially those containing Vitamin K) can alter how the drug works.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive maintenance therapy for venous thrombosis with or without pulmonary thromboembolism (PTE)
- Maintenance therapy for feline arterial thromboembolism
- Long-term thromboprophylaxis
- Adjunctive therapy of thromboembolism
- Cardiogenic arterial thromboembolism
- Adjunctive treatment of laminitis
- Anticoagulant
- Adjunctive maintenance therapy for venous thrombosis with or without pulmonary thromboembolism (PTE)
- Adjunctive therapy of thromboemboli
- Prophylactic use in patients with glomerular disease and severe proteinuria
給藥方式
可能的副作用
- Dose-related hemorrhage (primary adverse effect)
- Anemia
- Thrombocytopenia
- Weakness
- Hematomas and ecchymoses
- Epistaxis (nosebleeds)
- Hematemesis (vomiting blood)
- Hematuria (blood in urine)
- Melena (dark, tarry stools)
- Hematochezia (fresh blood in stools)
- Hemarthrosis (bleeding into joints)
- Hemothorax
- Intracranial hemorrhage
- Pericardial hemorrhage
注意事項與禁忌
- Preexistent hemorrhagic tendencies or diseases
- Patients undergoing or contemplating eye or CNS surgery
- Major regional lumbar block anesthesia
- Surgery of large, open surfaces
- Active bleeding from the GI, respiratory, or GU tract
- Aneurysm
- Acute nephritis
- Cerebrovascular hemorrhage
- Blood dyscrasias
- Uncontrolled or malignant hypertension
- Hepatic insufficiency
- Pericardial effusion
- Pregnancy (Teratogenic - FDA Category X / Papich Class D)
藥物相互作用
- Acetaminophen, NSAIDs, Salicylates: May increase anticoagulant response (via protein displacement or platelet inhibition); increases bleeding risk.
- Fluoroquinolones, Macrolides (Azithromycin, Erythromycin), Chloramphenicol, Sulfonamides, Co-trimoxazole: May increase anticoagulant response (often via inhibition of hepatic metabolism).
- Cimetidine, Cisapride, Fluoxetine, Metronidazole, Sertraline: May increase anticoagulant response.
- Amiodarone, Allopurinol, Danazol, Diazoxide, Ethacrynic acid, Pentoxifylline, Propylthiouracil, Quinidine, Zafirlukast: May increase anticoagulant response.
- Anabolic Steroids, Thyroid Medications: May increase anticoagulant response.
- Heparin: Increases anticoagulant response; often used concurrently during the initial overlap phase but requires careful monitoring.
- Barbiturates (e.g., Phenobarbital), Rifampin, Griseofulvin: May decrease anticoagulant response (via induction of hepatic metabolizing enzymes).
- Corticosteroids, Estrogens, Mercaptopurine, Spironolactone, Sucralfate: May decrease anticoagulant response.
- Vitamin K: Directly antagonizes warfarin, decreasing its anticoagulant response (used as an antidote for overdose).
常見問題
Warfarin Sodium用於寵物有甚麼用途？
> **Critical Warning:** Warfarin is a potent blood thinner. Strict adherence to the prescribed dosing schedule is absolutely essential. Do not skip doses or give extra doses without consulting your veterinarian. * **Watch for Bleeding:** Immediately report any signs of bleeding to your veterinarian. This includes pale gums, unusual bruising, nosebleeds, blood in the urine or stool (which may look black and tarry), vomiting blood, coughing up blood, or sudden weakness/lethargy. * **Prevent Trauma:** Keep pets (especially cats) indoors and restrict rough play to minimize the risk of traumatic injury, which could lead to severe bleeding. * **Medication Interactions:** Do not give your pet any new medications, supplements, or over-the-counter drugs (especially aspirin or other pain relievers) without checking with your veterinarian, as many drugs interact dangerously with warfarin. * **Diet:** Keep your pet's diet consistent, as sudden changes in food (especially those containing Vitamin K) can alter how the drug works.
Warfarin Sodium對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。