セベラマー

使用用途

• Hyperphosphatemia
• Chronic kidney disease (hyperphosphataemia)
• Hyperphosphatemia
• Chronic kidney disease (hyperphosphataemia)

投与方法

考えられる副作用

• Gastrointestinal upset (nausea, vomiting, diarrhea, or constipation)
• Decreased absorption of fat-soluble vitamins (A, D, E, K) and folic acid
• Constipation
• Pills are hygroscopic and will expand (potential risk of esophageal obstruction if not swallowed quickly)

注意事項と禁忌

• Hypophosphatemia
• Bowel obstruction
• Known hypersensitivity to sevelamer
• Gastrointestinal obstruction
• > **Pregnancy & Nursing**: Safety during pregnancy is not established (FDA Category C). Because of the potential for binding vitamins, additional vitamins (both fat and water-soluble) may be necessary for pregnant or nursing animals. * **Vitamin K Deficiency**: Because sevelamer can bind fat-soluble vitamins, it may impact Vitamin K absorption, potentially affecting coagulation. * **Administration Timing**: Must be given with meals to be effective at binding dietary phosphorus.

薬物相互作用

• Anticonvulsants (oral): Sevelamer may reduce oral absorption; give at least 1 hour before or 3 hours after sevelamer.
• Antiarrhythmics (oral): Sevelamer may reduce oral absorption; give at least 1 hour before or 3 hours after sevelamer.
• Ciprofloxacin (and other oral fluoroquinolones): Concurrent administration may decrease absorption by 50%; administer at least 1 hour before or 3 hours after sevelamer.
• Oral Medications (Narrow Therapeutic Index): May reduce absorption; consider dosing other oral drugs separately.
• Vitamins: Sevelamer may reduce vitamin absorption from food; consider administering vitamin supplements separately.
• Other oral medications: May bind to and decrease the absorption of concurrently administered oral drugs. Should be given at least 1 hour before or 3 hours after other medications.
• Fat-soluble vitamins (e.g., Vitamin K): May inhibit vitamin absorption; consider monitoring prothrombin time.

よくある質問