セレギリン

使用用途

• Behavioural disorders and cognitive dysfunction
• Cognitive decline in older cats

投与方法

考えられる副作用

• No specific adverse reactions are listed in the monograph
• Clinical Pearl: May occasionally cause mild gastrointestinal upset, restlessness, or lethargy

注意事項と禁忌

• Known sensitivity to selegiline
• Lactating bitches (acts on prolactin secretion)
• Pregnant bitches
• Normal safety and handling precautions should be observed. > **Warning:** Do not use in pregnant or lactating bitches due to its effects on prolactin secretion. Strict washout periods are required when switching to or from other psychoactive medications (e.g., TCAs, SSRIs).

薬物相互作用

• Alpha-2 antagonists: Should not be administered concurrently or within 24 hours before/after use
• Pethidine: Contraindicated concurrent use
• Ephedrine: Contraindicated concurrent use
• Amitraz: Potential MAOI interaction; contraindicated
• Phenothiazines: Contraindicated concurrent use
• Morphine: Potentiates the effect of morphine
• Metronidazole: Potential interaction exists
• Prednisolone: Potential interaction exists
• Trimethoprim: Potential interaction exists
• Tricyclic antidepressants (amitriptyline, doxepin, clomipramine): Do not use selegiline for at least 2-3 weeks after TCA use
• Fluoxetine: Do not use selegiline for at least 6 weeks after long-term fluoxetine use

よくある質問