リン酸ジソピラミド

使用用途

• Antiarrhythmic (almost never used)

投与方法

考えられる副作用

• Dry mouth, eyes, or nose
• Constipation
• Urinary hesitancy or retention
• Urinary frequency and urgency
• Edema
• Hypotension
• Dyspnea
• Syncope
• Conduction disturbances (e.g., AV block)
• Vomiting and diarrhea
• Intrahepatic cholestasis
• Hypoglycemia
• Fatigue and headache
• Muscle weakness and pain

注意事項と禁忌

• Hypersensitivity to the drug
• 2nd or 3rd degree AV block (unless a pacemaker is inserted)
• Cardiogenic shock
• Severe uncompensated or poorly compensated cardiac failure
• Hypotension
• Glaucoma (closed-angle)
• Urinary retention
• Myasthenia gravis
• Use with extreme caution in patients with sick sinus syndrome, bundle branch block, or Wolff-Parkinson-White (WPW) syndrome. Patients with atrial fibrillation or flutter must be digitalized before disopyramide therapy to negate increased ventricular response. Use with caution (and possibly at a reduced dosage) in patients with hepatic or renal disease. Use with caution in nursing animals as the drug is excreted in milk.

薬物相互作用

• Anticholinergic drugs (atropine, glycopyrrolate): Additive anticholinergic effects may be encountered.
• Cisapride: Additional prolongation of the QT interval.
• Macrolide antibiotics (erythromycin, clarithromycin): Increased disopyramide levels; prolongation of QT interval may occur.
• Phenobarbital: May increase disopyramide's metabolism and reduce serum levels.
• Procainamide, Lidocaine: May be used concurrently, but widening of QRS and prolongation of QT interval may occur.
• Quinidine: May increase disopyramide levels; disopyramide may decrease quinidine levels.
• Rifampin: May increase disopyramide's metabolism and reduce serum levels.
• Verapamil: Because of additional negative inotropic effects, use of disopyramide within 48 hours of using verapamil is not recommended.
• Propranolol: May cause additive negative inotropic effects.

よくある質問