Disopyramide Phosphate
別名: Norpace, Norpace CR, Dicorantil, Dirythmin, Dirytmin, DisoDuriles, Disomet, Disonorm, Durbis, Isomide, Isorythm, Ritmodan, Ritmoforine, Rythmical, Rythmodan, Rythmodul
> **Important**: This medication must be given on a strict schedule due to how quickly it leaves your dog's body. Do not skip doses or double up on missed doses. * **Watch for side effects**: Because of how this drug works, it can cause "drying" effects. Contact your veterinarian if your pet experiences dry mouth, dry eyes, constipation, or difficulty urinating. * **Monitor breathing and energy**: If your pet becomes unusually lethargic, depressed, or has difficulty breathing, seek veterinary care immediately, as this could indicate an adverse effect on the heart's pumping ability or blood pressure.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Antiarrhythmic (almost never used)
給藥方式
可能的副作用
- Dry mouth, eyes, or nose
- Constipation
- Urinary hesitancy or retention
- Urinary frequency and urgency
- Edema
- Hypotension
- Dyspnea
- Syncope
- Conduction disturbances (e.g., AV block)
- Vomiting and diarrhea
- Intrahepatic cholestasis
- Hypoglycemia
- Fatigue and headache
- Muscle weakness and pain
注意事項與禁忌
- Hypersensitivity to the drug
- 2nd or 3rd degree AV block (unless a pacemaker is inserted)
- Cardiogenic shock
- Severe uncompensated or poorly compensated cardiac failure
- Hypotension
- Glaucoma (closed-angle)
- Urinary retention
- Myasthenia gravis
- Use with extreme caution in patients with sick sinus syndrome, bundle branch block, or Wolff-Parkinson-White (WPW) syndrome. Patients with atrial fibrillation or flutter must be digitalized before disopyramide therapy to negate increased ventricular response. Use with caution (and possibly at a reduced dosage) in patients with hepatic or renal disease. Use with caution in nursing animals as the drug is excreted in milk.
藥物相互作用
- Anticholinergic drugs (atropine, glycopyrrolate): Additive anticholinergic effects may be encountered.
- Cisapride: Additional prolongation of the QT interval.
- Macrolide antibiotics (erythromycin, clarithromycin): Increased disopyramide levels; prolongation of QT interval may occur.
- Phenobarbital: May increase disopyramide's metabolism and reduce serum levels.
- Procainamide, Lidocaine: May be used concurrently, but widening of QRS and prolongation of QT interval may occur.
- Quinidine: May increase disopyramide levels; disopyramide may decrease quinidine levels.
- Rifampin: May increase disopyramide's metabolism and reduce serum levels.
- Verapamil: Because of additional negative inotropic effects, use of disopyramide within 48 hours of using verapamil is not recommended.
- Propranolol: May cause additive negative inotropic effects.
常見問題
Disopyramide Phosphate用於寵物有甚麼用途？
> **Important**: This medication must be given on a strict schedule due to how quickly it leaves your dog's body. Do not skip doses or double up on missed doses. * **Watch for side effects**: Because of how this drug works, it can cause "drying" effects. Contact your veterinarian if your pet experiences dry mouth, dry eyes, constipation, or difficulty urinating. * **Monitor breathing and energy**: If your pet becomes unusually lethargic, depressed, or has difficulty breathing, seek veterinary care immediately, as this could indicate an adverse effect on the heart's pumping ability or blood pressure.
Disopyramide Phosphate對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。