雙異丙吡胺磷酸鹽
別名: Norpace, Norpace CR, Dicorantil, Dirythmin, Dirytmin, DisoDuriles, Disomet, Disonorm, Durbis, Isomide, Isorythm, Ritmodan, Ritmoforine, Rythmical, Rythmodan, Rythmodul
> **重要提示**：由於此藥物在狗狗體內代謝非常快，必須嚴格按照時間表給藥。請勿漏服或在漏服後服用雙倍劑量。 * **注意副作用**：由於此藥物的作用機制，它可能會引起「乾燥」效應。如果您的寵物出現口乾、眼乾、便秘或排尿困難，請聯繫您的獸醫。 * **監測呼吸和活力**：如果您的寵物變得異常嗜睡、抑鬱或呼吸困難，請立即尋求獸醫協助，因為這可能表明心臟泵血能力或血壓受到了不良影響。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
Veterinary professional? See the full dosing-by-species reference on VetSheet →
用途
- Antiarrhythmic (almost never used)
給藥方式
可能的副作用
- Dry mouth, eyes, or nose
- Constipation
- Urinary hesitancy or retention
- Urinary frequency and urgency
- Edema
- Hypotension
- Dyspnea
- Syncope
- Conduction disturbances (e.g., AV block)
- Vomiting and diarrhea
- Intrahepatic cholestasis
- Hypoglycemia
- Fatigue and headache
- Muscle weakness and pain
- Prolonged QT interval (at 15 mg/kg q8h in dogs)
- Widened QRS complex (at doses >30 mg/kg in dogs)
注意事項與禁忌
- Hypersensitivity to the drug
- 2nd or 3rd degree AV block (unless a pacemaker is inserted)
- Cardiogenic shock
- Severe uncompensated or poorly compensated cardiac failure
- Hypotension
- Glaucoma (closed-angle)
- Urinary retention
- Myasthenia gravis
- Use with extreme caution in patients with sick sinus syndrome, bundle branch block, or Wolff-Parkinson-White (WPW) syndrome. Patients with atrial fibrillation or flutter must be digitalized before disopyramide therapy to negate increased ventricular response. Use with caution (and possibly at a reduced dosage) in patients with hepatic or renal disease. Use with caution in nursing animals as the drug is excreted in milk.
藥物相互作用
- Anticholinergic drugs (atropine, glycopyrrolate): Additive anticholinergic effects may be encountered.
- Cisapride: Additional prolongation of the QT interval.
- Macrolide antibiotics (erythromycin, clarithromycin): Increased disopyramide levels; prolongation of QT interval may occur.
- Phenobarbital: May increase disopyramide's metabolism and reduce serum levels.
- Procainamide, Lidocaine: May be used concurrently, but widening of QRS and prolongation of QT interval may occur.
- Quinidine: May increase disopyramide levels; disopyramide may decrease quinidine levels.
- Rifampin: May increase disopyramide's metabolism and reduce serum levels.
- Verapamil: Because of additional negative inotropic effects, use of disopyramide within 48 hours of using verapamil is not recommended.
- Propranolol: May cause additive negative inotropic effects.
常見問題
雙異丙吡胺磷酸鹽用於寵物有什麼用途？
> 重要提示：由於此藥物在狗狗體內代謝非常快，必須嚴格按照時間表給藥。請勿漏服或在漏服後服用雙倍劑量。 • 注意副作用：由於此藥物的作用機制，它可能會引起「乾燥」效應。如果您的寵物出現口乾、眼乾、便秘或排尿困難，請聯繫您的獸醫。 • 監測呼吸和活力：如果您的寵物變得異常嗜睡、抑鬱或呼吸困難，請立即尋求獸醫協助，因為這可能表明心臟泵血能力或血壓受到了不良影響。
雙異丙吡胺磷酸鹽對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。