ジフェノキシレートおよびアトロピン

使用用途

• As an antidiarrheal
• As an antidiarrheal
• As an antidiarrheal
• As an antidiarrheal
• As an antidiarrheal
• As an antitussive
• As an antitussive

投与方法

考えられる副作用

• Constipation
• Bloat
• Sedation
• Paralytic ileus (potential)
• Toxic megacolon (potential)
• Pancreatitis (potential)
• CNS depression or excitation
• Excitatory behavior (especially in cats)

注意事項と禁忌

• Known hypersensitivity to narcotic analgesics
• Patients receiving monoamine oxidase inhibitors (MAOIs)
• Diarrhea caused by toxic ingestion (until the toxin is eliminated from the GI tract)
• Intestinal obstruction
• Bacterial-induced acute diarrhea (may enhance bacterial proliferation)
• Use with caution in patients with **respiratory disease**, **hepatic encephalopathy** (hepatic coma may result), **hypothyroidism**, **severe renal insufficiency**, **adrenocortical insufficiency (Addison's disease)**, **head injuries or increased intracranial pressure**, **acute abdominal conditions** (may obscure diagnosis), and in **geriatric or severely debilitated patients**. * **Small Dogs**: Extreme care is required when dosing dogs under 10 kg; liquid formulations are recommended for accurate titration. * **Cats**: Use is controversial and generally not recommended due to potential excitatory behavior. * **Horses/Infectious Diarrhea**: Opiates may have a detrimental effect in acute diarrhea by enhancing bacterial proliferation, delaying microbe clearance, and prolonging the febrile state. * **Nursing/Pregnancy**: Category C. Excreted in maternal milk; use caution in nursing patients.

薬物相互作用

• CNS Depressant Drugs (anesthetics, antihistamines, phenothiazines, barbiturates, tranquilizers, alcohol): May cause increased CNS or respiratory depression when used concurrently.
• Monoamine Oxidase Inhibitors (MAOIs) (e.g., amitraz, selegiline): Contraindicated. Do not use opiate antidiarrheals for at least 14 days after receiving MAOIs due to risk of severe adverse reactions.

よくある質問