シスプラチン

使用用途

• For intralesional injection of skin tumors
• For potentially susceptible carcinomas and sarcomas
• Intracavitary administration for palliative control of neoplastic pulmonary effusions

投与方法

考えられる副作用

• Severe vomiting (acute and delayed)
• Nephrotoxicity (renal tubular damage)
• Myelosuppression (thrombocytopenia, granulocytopenia)
• Ototoxicity (high-frequency hearing loss, tinnitus)
• Anorexia
• Diarrhea (including hemorrhagic)
• Seizures
• Peripheral neuropathies
• Electrolyte abnormalities
• Hyperuricemia
• Increased hepatic enzymes
• Anaphylactoid reactions
• Death

注意事項と禁忌

• Cats (causes fatal pulmonary edema and dyspnea)
• Preexisting significant renal impairment
• Preexisting myelosuppression
• History of hypersensitivity to platinum-containing compounds
• Caution in patients with congestive heart failure (due to required fluid loading)
• > **WARNING: FATAL TO CATS.** Do not administer to felines under any circumstances. * **Nephrotoxicity:** Mandatory saline diuresis is required before and after IV therapy in dogs. * **Administration Rate:** Direct IV infusion over <5 minutes should be avoided as it increases nephrotoxicity and ototoxicity. * **Handling:** Wear gloves and protective clothing. Wash thoroughly with soap and water if accidental exposure occurs. * **Equipment:** Do NOT use aluminum hub needles or aluminum-containing IV sets; aluminum displaces platinum, forming a black precipitate. * **Reproductive Safety:** Teratogenic, embryotoxic, and may cause azoospermia. Use extreme caution.

薬物相互作用

• Aminoglycosides: Potential for increased risk for nephrotoxicity; if possible, delay aminoglycoside administration by at least two weeks after cisplatin.
• Amphotericin B: Potential for increased risk for nephrotoxicity; if possible, delay amphotericin B administration by at least two weeks after cisplatin.
• Furosemide (and other loop diuretics): Potential for increased ototoxicity.
• Phenytoin: Cisplatin may reduce serum levels of phenytoin.

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