Propantheline Bromide
Also known as: Pro-Banthine
> **Important:** Propantheline is used to treat diarrhea, urinary incontinence, or slow heart rates. It works by relaxing smooth muscles and decreasing gland secretions. * **Dry Mouth:** Your pet may experience a dry mouth. This can be relieved by applying small amounts of water to your animal's tongue for 10-15 minutes. * **Monitor for Worsening Signs:** Protracted vomiting and diarrhea can be serious. Contact your veterinarian immediately if symptoms are not alleviated or if they worsen. * **Other Side Effects:** Watch for constipation, difficulty urinating, or a racing heart rate. Cats may occasionally drool or vomit after taking this medication. * **Administration:** Give exactly as prescribed. Do not stop the medication abruptly without consulting your veterinarian.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Detrusor hyperreflexia, urge incontinence
- Detrusor hyperreflexia, urge incontinence
- Detrusor hyperreflexia, urge incontinence
- Sinus bradycardia, incomplete AV block, etc.
- Sinus bradycardia, incomplete AV block, etc.
- Chronic colitis
- As an antiemetic/antidiarrheal
- To reduce rectal contractions during oocyte collection
- To inhibit peristalsis for 2 hours during rectal surgery
- Detrusor hyperreflexia, urge incontinence
- Detrusor hyperreflexia, urge incontinence
- Detrusor hyperreflexia, urge incontinence
- Sinus bradycardia, incomplete AV block, etc.
How it is given
Possible side effects
- Dry mouth (xerostomia)
- Dry eyes (keratoconjunctivitis sicca)
- Urinary hesitancy or retention
- Tachycardia
- Constipation
- Vomiting (especially in cats)
- Hypersalivation (especially in cats)
- Ileus (at high doses, potentially leading to bacterial overgrowth)
Cautions & contraindications
- Hypersensitivity to anticholinergics
- Tachycardias secondary to thyrotoxicosis or cardiac insufficiency
- Myocardial ischemia
- Unstable cardiac status during acute hemorrhage
- Gastrointestinal obstructive disease
- Paralytic ileus
- Severe ulcerative colitis
- Obstructive uropathy
- Myasthenia gravis (unless used to reverse adverse muscarinic effects secondary to therapy)
- **Extreme Caution:** * **GI Infections:** Can decrease GI motility and prolong retention of causative agents or toxins, worsening clinical signs. * **Autonomic Neuropathy:** Use with extreme caution. **Caution:** * Hepatic or renal disease * Hyperthyroidism * Hypertension * Congestive Heart Failure (CHF) * Tachyarrhythmias * Prostatic hypertrophy * Esophageal reflux * Geriatric or pediatric patients * Nursing patients (unknown if excreted in milk, but anticholinergics can reduce milk production and cause toxicity in neonates)
Drug interactions
- Antihistamines: May enhance the anticholinergic activity of propantheline.
- Benzodiazepines: May enhance the activity of propantheline.
- Cimetidine: Propantheline may decrease the absorption of cimetidine.
- Corticosteroids: Long-term concurrent use may increase intraocular pressure.
- Meperidine: May enhance the activity of propantheline.
- Nitrates: May potentiate the adverse effects of propantheline.
- Nitrofurantoin: Propantheline may enhance the actions of nitrofurantoin.
- Phenothiazines: May enhance the anticholinergic activity of propantheline.
- Sympathomimetics: Propantheline may enhance their actions.
- Ranitidine: Propantheline delays absorption but increases peak serum levels of ranitidine; relative bioavailability of ranitidine may increase by 23%.
- Thiazide Diuretics: Propantheline may enhance their actions.
Frequently asked questions
What is Propantheline Bromide used for in pets?
> **Important:** Propantheline is used to treat diarrhea, urinary incontinence, or slow heart rates. It works by relaxing smooth muscles and decreasing gland secretions. * **Dry Mouth:** Your pet may experience a dry mouth. This can be relieved by applying small amounts of water to your animal's tongue for 10-15 minutes. * **Monitor for Worsening Signs:** Protracted vomiting and diarrhea can be serious. Contact your veterinarian immediately if symptoms are not alleviated or if they worsen. * **Other Side Effects:** Watch for constipation, difficulty urinating, or a racing heart rate. Cats may occasionally drool or vomit after taking this medication. * **Administration:** Give exactly as prescribed. Do not stop the medication abruptly without consulting your veterinarian.
Is Propantheline Bromide safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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