프로판텔린 브로마이드

용도

• Detrusor hyperreflexia, urge incontinence
• Detrusor hyperreflexia, urge incontinence
• Detrusor hyperreflexia, urge incontinence
• Sinus bradycardia, incomplete AV block, etc.
• Sinus bradycardia, incomplete AV block, etc.
• Chronic colitis
• As an antiemetic/antidiarrheal
• To reduce rectal contractions during oocyte collection
• To inhibit peristalsis for 2 hours during rectal surgery
• Detrusor hyperreflexia, urge incontinence
• Detrusor hyperreflexia, urge incontinence
• Detrusor hyperreflexia, urge incontinence
• Sinus bradycardia, incomplete AV block, etc.

투여 방법

가능한 부작용

• Dry mouth (xerostomia)
• Dry eyes (keratoconjunctivitis sicca)
• Urinary hesitancy or retention
• Tachycardia
• Constipation
• Vomiting (especially in cats)
• Hypersalivation (especially in cats)
• Ileus (at high doses, potentially leading to bacterial overgrowth)

주의사항 및 금기

• Hypersensitivity to anticholinergics
• Tachycardias secondary to thyrotoxicosis or cardiac insufficiency
• Myocardial ischemia
• Unstable cardiac status during acute hemorrhage
• Gastrointestinal obstructive disease
• Paralytic ileus
• Severe ulcerative colitis
• Obstructive uropathy
• Myasthenia gravis (unless used to reverse adverse muscarinic effects secondary to therapy)
• **Extreme Caution:** * **GI Infections:** Can decrease GI motility and prolong retention of causative agents or toxins, worsening clinical signs. * **Autonomic Neuropathy:** Use with extreme caution. **Caution:** * Hepatic or renal disease * Hyperthyroidism * Hypertension * Congestive Heart Failure (CHF) * Tachyarrhythmias * Prostatic hypertrophy * Esophageal reflux * Geriatric or pediatric patients * Nursing patients (unknown if excreted in milk, but anticholinergics can reduce milk production and cause toxicity in neonates)

약물 상호작용

• Antihistamines: May enhance the anticholinergic activity of propantheline.
• Benzodiazepines: May enhance the activity of propantheline.
• Cimetidine: Propantheline may decrease the absorption of cimetidine.
• Corticosteroids: Long-term concurrent use may increase intraocular pressure.
• Meperidine: May enhance the activity of propantheline.
• Nitrates: May potentiate the adverse effects of propantheline.
• Nitrofurantoin: Propantheline may enhance the actions of nitrofurantoin.
• Phenothiazines: May enhance the anticholinergic activity of propantheline.
• Sympathomimetics: Propantheline may enhance their actions.
• Ranitidine: Propantheline delays absorption but increases peak serum levels of ranitidine; relative bioavailability of ranitidine may increase by 23%.
• Thiazide Diuretics: Propantheline may enhance their actions.

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