Isoflupredone Acetate
Also known as: Predef 2X
> **Important Note**: This medication is a potent steroid and must be used exactly as prescribed by your veterinarian. * **Dairy Cattle**: Be aware that milk production may temporarily decrease following administration. * **Horses & Swine**: Monitor for signs of weakness, muscle trembling, or lethargy, which could indicate low blood potassium (hypokalemia). * **General Monitoring**: Watch for increased thirst, increased urination, or changes in appetite. * If you are administering the medication at home, follow your veterinarian's directions strictly. Do not abruptly stop this medication if it has been given for an extended period without consulting your vet.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Labeled systemic indications
- Labeled systemic indications
- Intrasynovial administration
- Intraarticular administration
- Treatment of 'heaves' (RAO)
- Treatment of recurrent airway obstruction (RAO)
- Labeled systemic indications
How it is given
Possible side effects
- Hypokalemia (even with single doses)
- Reduced milk production
- Delayed wound healing
- Gastrointestinal ulceration
- Increased infection rates
- Diabetes mellitus exacerbation / hyperglycemia
- Pancreatitis
- Hepatopathy
- Renal dysfunction
- Osteoporosis
- Laminitis (horses)
- Hypothyroidism
- Hyperlipidemia
- Decreased growth in young animals
Cautions & contraindications
- Systemic fungal infections (unless used for Addison's replacement)
- Idiopathic thrombocytopenia (when administered IM)
- Hypersensitivity to the compound
- Downer cows or animals susceptible to hypokalemia
- Calves to be processed into veal
- Late stages of pregnancy (relative contraindication)
- Use with extreme caution in patients with active GI ulcers or those susceptible to them. Use cautiously in patients with diabetes mellitus. Because it can cause hypokalemia, it should not be used in downer cows or animals susceptible to the effects of hypokalemia. Chronic use in young, growing animals must be undertaken cautiously, as decreased growth may occur. Avoid using during pregnancy as it may induce premature parturition with retained placenta.
Drug interactions
- Digitalis glycosides (digoxin): Increased chance of digitalis toxicity may occur should hypokalemia develop; diligent monitoring of potassium and digitalis glycoside levels is recommended
- Potassium-depleting diuretics (furosemide, thiazides): Administered concomitantly with glucocorticoids may cause hypokalemia
- Salicylates: Glucocorticoids may reduce salicylate blood levels
- Ulcerogenic drugs (e.g., NSAIDs): With glucocorticoids may increase the risk of gastrointestinal ulceration
- Vaccines, toxoids, bacterins: A diminished immune response may occur; patients receiving immunosuppressive dosages should generally not receive live attenuated-virus vaccines
Frequently asked questions
What is Isoflupredone Acetate used for in pets?
> **Important Note**: This medication is a potent steroid and must be used exactly as prescribed by your veterinarian. * **Dairy Cattle**: Be aware that milk production may temporarily decrease following administration. * **Horses & Swine**: Monitor for signs of weakness, muscle trembling, or lethargy, which could indicate low blood potassium (hypokalemia). * **General Monitoring**: Watch for increased thirst, increased urination, or changes in appetite. * If you are administering the medication at home, follow your veterinarian's directions strictly. Do not abruptly stop this medication if it has been given for an extended period without consulting your vet.
Is Isoflupredone Acetate safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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