Eprinomectin
Also known as: Ivomec Eprinex, Broadline, NexGard Combo (contains eprinomectin)
- **Zero Withdrawal**: When used as directed in cattle, there is no need to withhold milk or meat. - **Weather Resistant**: Rainfall or weather conditions during or after application do not reduce the medication's effectiveness. - **Application Rules**: Apply directly to the backline. **Do not** apply to areas covered with heavy mud or manure, as this can block absorption. - > **Environmental Warning**: Eprinomectin is highly toxic to fish and aquatic organisms. Dispose of all empty containers properly (e.g., approved landfill or incineration) and never contaminate water sources.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Treatment and prevention of fleas, ticks, nematodes (including feline lungworm and Capillaria plica), and prevention of heartworm disease
- Treatment of psoroptic (P. equi) mange
- Ear mites (Psoroptes cuniculi) in rabbits
- Labeled indications (gastrointestinal roundworms, cattle grubs, lice, mange mites, horn flies, lungworms)
How it is given
Possible side effects
- Ineffectiveness for parasite control (reported in FDA database)
- Anorexia
- Udder hypogalactia
- Mild clumping of the hair at the application site
Cautions & contraindications
- Oral administration
- Intravenous administration
- Cats weighing < 0.6 kg
- Kittens < 7 weeks of age
- Dogs (not intended for use)
- > **Warning:** Do not administer orally or intravenously. Highly toxic to fish and aquatic organisms; dispose of containers properly.
Drug interactions
- ciclosporin: Potential interaction as both are P-glycoprotein substrates; none reported clinically
- itraconazole: Potential interaction as both are P-glycoprotein substrates; none reported clinically
- loperamide: Potential interaction as both are P-glycoprotein substrates; none reported clinically
- steroids: Potential interaction as both are P-glycoprotein substrates; none reported clinically
- opiates: Potential interaction as both are P-glycoprotein substrates; none reported clinically
- P-glycoprotein substrates (e.g., ciclosporin, itraconazole, loperamide, steroids, opiates): Theoretical potential for interaction due to shared P-glycoprotein efflux pump mechanisms, though none have been clinically reported.
Frequently asked questions
What is Eprinomectin used for in pets?
- **Zero Withdrawal**: When used as directed in cattle, there is no need to withhold milk or meat. - **Weather Resistant**: Rainfall or weather conditions during or after application do not reduce the medication's effectiveness. - **Application Rules**: Apply directly to the backline. **Do not** apply to areas covered with heavy mud or manure, as this can block absorption. - > **Environmental Warning**: Eprinomectin is highly toxic to fish and aquatic organisms. Dispose of all empty containers properly (e.g., approved landfill or incineration) and never contaminate water sources.
Is Eprinomectin safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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