Deracoxib
Also known as: Deramaxx
**Storage Warning**: These tablets are highly flavored and dogs may eat the entire bottle if they find it. **Keep strictly out of reach of pets and children.** * **Administration**: Although it can be given on an empty stomach, it is preferable to give with food to enhance absorption and protect the stomach. Ensure fresh water is always available to avoid dehydration. * **What to Watch For**: Stop the medication and contact your vet immediately if you notice: * Vomiting or loss of appetite * Black, tarry stools or bloody diarrhea * Changes in drinking or urination habits * Lethargy or behavioral changes * Signs of allergic reaction (facial swelling, hives, red/itchy skin) * **Do Not Mix**: Never give this medication with other pain medications, NSAIDs (like human aspirin/ibuprofen), or steroids without explicit veterinary approval. * **Dosing**: Do not increase or alter the dose without veterinary approval.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Control of pain and inflammation associated with osteoarthritis
- Treatment of post-operative pain
How it is given
Possible side effects
- Vomiting
- Anorexia/weight loss
- Diarrhea
- Melena
- Hematemesis
- Hematochezia
- GI ulceration/perforation
- Azotemia
- Polydipsia/polyuria
- Urinary tract infection (UTI)
- Hematuria
- Urinary incontinence
- Renal failure
- Anemia
- Thrombocytopenia
Cautions & contraindications
- Known hypersensitivity to deracoxib
- Use with caution in patients with concurrent **GI ulcerative diseases**, **renal or hepatic dysfunction**, those in **hypoproteinemic states**, or with conditions that may predispose them to **hypercoagulability**. Safety in pregnant or nursing animals has not been established. Avoid concurrent use with other NSAIDs or corticosteroids.
Drug interactions
- ACE Inhibitors (e.g., enalapril, benazepril): NSAIDs can reduce effects on blood pressure. Concurrent use may increase the risk for renal injury due to reduced renal blood flow.
- Aspirin: May increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea). A multi-day washout period is warranted when switching.
- Corticosteroids (e.g., prednisone): May significantly increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea).
- Digoxin: NSAIDs may increase serum levels of digoxin.
- Fluconazole: May increase plasma levels of deracoxib (extrapolated from human celecoxib data).
- Furosemide: NSAIDs may reduce saluretic and diuretic effects.
- Methotrexate: Serious toxicity has occurred when NSAIDs are used concomitantly; use with extreme caution.
- Nephrotoxic Drugs (e.g., aminoglycosides, amphotericin B): May enhance the risk of developing nephrotoxicity.
- Other NSAIDs: May increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea).
Frequently asked questions
What is Deracoxib used for in pets?
**Storage Warning**: These tablets are highly flavored and dogs may eat the entire bottle if they find it. **Keep strictly out of reach of pets and children.** * **Administration**: Although it can be given on an empty stomach, it is preferable to give with food to enhance absorption and protect the stomach. Ensure fresh water is always available to avoid dehydration. * **What to Watch For**: Stop the medication and contact your vet immediately if you notice: * Vomiting or loss of appetite * Black, tarry stools or bloody diarrhea * Changes in drinking or urination habits * Lethargy or behavioral changes * Signs of allergic reaction (facial swelling, hives, red/itchy skin) * **Do Not Mix**: Never give this medication with other pain medications, NSAIDs (like human aspirin/ibuprofen), or steroids without explicit veterinary approval. * **Dosing**: Do not increase or alter the dose without veterinary approval.
Is Deracoxib safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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