デラコキシブ

使用用途

• Control of pain and inflammation associated with osteoarthritis
• Treatment of post-operative pain

投与方法

考えられる副作用

• Vomiting
• Anorexia/weight loss
• Diarrhea
• Melena
• Hematemesis
• Hematochezia
• GI ulceration/perforation
• Azotemia
• Polydipsia/polyuria
• Urinary tract infection (UTI)
• Hematuria
• Urinary incontinence
• Renal failure
• Anemia
• Thrombocytopenia

注意事項と禁忌

• Known hypersensitivity to deracoxib
• Use with caution in patients with concurrent **GI ulcerative diseases**, **renal or hepatic dysfunction**, those in **hypoproteinemic states**, or with conditions that may predispose them to **hypercoagulability**. Safety in pregnant or nursing animals has not been established. Avoid concurrent use with other NSAIDs or corticosteroids.

薬物相互作用

• ACE Inhibitors (e.g., enalapril, benazepril): NSAIDs can reduce effects on blood pressure. Concurrent use may increase the risk for renal injury due to reduced renal blood flow.
• Aspirin: May increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea). A multi-day washout period is warranted when switching.
• Corticosteroids (e.g., prednisone): May significantly increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea).
• Digoxin: NSAIDs may increase serum levels of digoxin.
• Fluconazole: May increase plasma levels of deracoxib (extrapolated from human celecoxib data).
• Furosemide: NSAIDs may reduce saluretic and diuretic effects.
• Methotrexate: Serious toxicity has occurred when NSAIDs are used concomitantly; use with extreme caution.
• Nephrotoxic Drugs (e.g., aminoglycosides, amphotericin B): May enhance the risk of developing nephrotoxicity.
• Other NSAIDs: May increase the risk of gastrointestinal toxicity (ulceration, bleeding, vomiting, diarrhea).

よくある質問