Cloxacillin
Also known as: Orbenin-DC, Dry-Clox, Dariclox, Boviclox, Opticlox, Orbenin
> **Important:** If using oral compounded formulations for pets, complete the entire prescription even if the pet feels better. - **Food Animals:** Adhere strictly to withdrawal times. Dry cow products (benzathine) require a 28-30 day slaughter withdrawal. Lactating cow products (sodium) require a 48-hour milk withdrawal and 10-day slaughter withdrawal. - **Allergic Reactions:** Watch for signs of allergy such as hives, facial swelling, or difficulty breathing. Contact your veterinarian immediately if these occur.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Susceptible infections
- Staph. pyoderma, diskospondylitis, osteoarthritis or skin infections
- Systemic infections, bacteremia
- Ocular infections
- Mastitis (treatment or prophylaxis) caused by susceptible organisms - Lactating cow
- Mastitis (treatment or prophylaxis) caused by susceptible organisms - Dry (non-lactating) cows
- Susceptible infections
- Staph. pyoderma, diskospondylitis, osteoarthritis or skin infections
- Systemic infections, bacteremia
- Ocular infections
How it is given
Possible side effects
- Hypersensitivity reactions (rashes, fever, anaphylaxis)
- Eosinophilia
- Neutropenia
- Agranulocytosis
- Thrombocytopenia
- Leukopenia
- Anemias
- Lymphadenopathy
- Hypersensitivity reactions
- Local irritation (ophthalmic)
Cautions & contraindications
- Known hypersensitivity to penicillins
- Known hypersensitivity to penicillins or cephalosporins
- > **Warning:** Contraindicated in patients with a history of hypersensitivity to penicillins. - **Cross-Reactivity:** Use cautiously in patients with documented hypersensitivity to other beta-lactam antibiotics (e.g., cephalosporins, cefamycins, carbapenems). In humans, 1-15% of cephalosporin-allergic patients cross-react with penicillins. - **Pregnancy:** FDA Category B (human); Papich Class A (veterinary). Generally considered safe, but use only when potential benefits outweigh risks. Crosses the placenta but no documented teratogenic problems.
Frequently asked questions
What is Cloxacillin used for in pets?
> **Important:** If using oral compounded formulations for pets, complete the entire prescription even if the pet feels better. - **Food Animals:** Adhere strictly to withdrawal times. Dry cow products (benzathine) require a 28-30 day slaughter withdrawal. Lactating cow products (sodium) require a 48-hour milk withdrawal and 10-day slaughter withdrawal. - **Allergic Reactions:** Watch for signs of allergy such as hives, facial swelling, or difficulty breathing. Contact your veterinarian immediately if these occur.
Is Cloxacillin safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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