Aminopentamide
Also known as: Centrine
Aminopentamide helps relieve stomach and intestinal cramps. * **Watch for side effects:** You may notice your pet has a dry mouth, dry eyes, or dilated pupils. * **Important:** Contact your veterinarian immediately if your pet strains to urinate, cannot urinate, or seems excessively uncomfortable, as this drug can cause urinary retention.
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
What it is used for
- Acute abdominal visceral spasm, nausea, vomiting, diarrhea
- Second-line adjunctive therapy for refractory IBD
- Acute abdominal visceral spasm, nausea, vomiting, diarrhea
- To decrease tenesmus in malabsorption/maldigestion syndromes
How it is given
Possible side effects
- Dry mouth (xerostomia)
- Dry eyes (keratoconjunctivitis sicca)
- Blurred vision (mydriasis)
- Urinary hesitancy or retention
- Tachycardia
- Decreased GI motility (constipation/ileus)
Cautions & contraindications
- Glaucoma (absolute contraindication)
- Pyloric obstruction
- Hypersensitivity to anticholinergic drugs
- Tachycardias secondary to thyrotoxicosis or cardiac insufficiency
- Myocardial ischemia
- Unstable cardiac status during acute hemorrhage
- GI obstructive disease
- Paralytic ileus
- Severe ulcerative colitis
- Obstructive uropathy
- Myasthenia gravis (unless used to reverse adverse muscarinic effects)
- Known or suspected GI infections (e.g., parvovirus enteritis)
- > **Warning:** Antimuscarinic agents can decrease GI motility, potentially prolonging the retention of toxins or infectious agents (e.g., parvovirus). Use with extreme caution in these cases. Use with caution in patients with: * Hepatic or renal disease * Hyperthyroidism * Hypertension * Congestive Heart Failure (CHF) or tachyarrhythmias * Prostatic hypertrophy * Esophageal reflux * Geriatric or pediatric patients
Drug interactions
- Antihistamines: May enhance the activity of anticholinergic derivatives
- Procainamide: May enhance the activity of anticholinergic derivatives
- Quinidine: May enhance the activity of anticholinergic derivatives
- Meperidine: May enhance the activity of anticholinergic derivatives
- Benzodiazepines: May enhance the activity of anticholinergic derivatives
- Phenothiazines: May enhance the activity of anticholinergic derivatives
- Primidone: May potentiate the adverse effects of anticholinergic derivatives
- Disopyramide: May potentiate the adverse effects of anticholinergic derivatives
- Nitrates: May potentiate the adverse effects of anticholinergic derivatives
- Corticosteroids (long-term use): May increase intraocular pressure
- Nitrofurantoin: Anticholinergic derivatives may enhance actions
Frequently asked questions
What is Aminopentamide used for in pets?
Aminopentamide helps relieve stomach and intestinal cramps. * **Watch for side effects:** You may notice your pet has a dry mouth, dry eyes, or dilated pupils. * **Important:** Contact your veterinarian immediately if your pet strains to urinate, cannot urinate, or seems excessively uncomfortable, as this drug can cause urinary retention.
Is Aminopentamide safe for my pet?
Dosage must be set by your veterinarian for your specific pet. Never give human medication or another pet’s prescription without veterinary guidance.
This article is for general education and is not a substitute for professional veterinary advice. If your pet is unwell, please consult a veterinarian.
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