丙卡巴肼
別名: Matulane, Natulan, Natulanar
藥物類別: Antineoplastic - Alkylating Agent
> **重要的安全警告**：丙卡巴肼是一種化療藥物。在家中必須採取嚴格的安全措施，以保護人類家庭成員的健康。 - **安全處理**：處理此藥物時請務必戴上拋棄式手套。給藥後請徹底洗手。 - **廢棄物管理**：給藥後的數天內，請避免直接接觸寵物的唾液、嘔吐物、尿液或糞便。清理排泄物時請戴上手套，並將廢棄物密封於塑膠袋中丟棄。 - **何時聯繫獸醫**：如果您的寵物出現中毒跡象，包括嘔吐、食慾不振、腹瀉、異常出血或瘀傷、嚴重抑鬱、焦躁不安、口腔潰瘍或跛行，請立即聯繫您的獸醫。 - **懷孕警告**：孕婦、哺乳期婦女及準備懷孕的人士應避免接觸此藥物。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- MOPP lymphoma rescue
- Lymphoma rescue (MOPP protocol)
- Granulomatous meningoencephalitis (GME)
給藥方式
PO
可能的副作用
- Nausea and vomiting
- Hepatotoxicity
- Myelosuppression (thrombocytopenia, leukopenia)
- Hemorrhagic gastritis
- CNS effects (sedation, agitation)
- Peripheral neuropathy (loss of tendon reflexes, paresthesias, myalgia)
注意事項與禁忌
- Known hypersensitivity to procarbazine
- Inadequate bone marrow reserve
- > **Hazardous Drug**: Procarbazine is a cytotoxic agent and a known teratogen (FDA Category D). Strict safe handling protocols must be followed by both veterinary staff and pet owners. - Use with extreme caution in patients with impaired **renal or hepatic function**. - Use with extreme caution when co-administering with other **CNS depressant drugs**. - Because it is often used in combination protocols (e.g., MOPP), myelosuppression and GI effects may be significantly enhanced.
藥物相互作用
- Alcohol/Ethanol: May cause severe nausea and vomiting (disulfiram-like reaction).
- CNS Depressant Drugs (barbiturates, opiates, antihistamines, phenothiazines): Procarbazine can cause CNS depression; concurrent use can lead to severe depression. Coma and death have been reported with opiates.
- Foods with high tyramine content (aged cheese, yogurt): Serious hypertension may result due to procarbazine's MAOI activity.
- Sympathomimetics (phenylpropanolamine, etc.): Serious hypertension may result due to procarbazine's MAOI activity.
- Tricyclic Antidepressants (clomipramine, amitriptyline): Do not use concurrently due to MAOI activity; risk of serotonin syndrome or hypertensive crisis.
常見問題
丙卡巴肼用於寵物有什麼用途？
> **重要的安全警告**：丙卡巴肼是一種化療藥物。在家中必須採取嚴格的安全措施，以保護人類家庭成員的健康。 - **安全處理**：處理此藥物時請務必戴上拋棄式手套。給藥後請徹底洗手。 - **廢棄物管理**：給藥後的數天內，請避免直接接觸寵物的唾液、嘔吐物、尿液或糞便。清理排泄物時請戴上手套，並將廢棄物密封於塑膠袋中丟棄。 - **何時聯繫獸醫**：如果您的寵物出現中毒跡象，包括嘔吐、食慾不振、腹瀉、異常出血或瘀傷、嚴重抑鬱、焦躁不安、口腔潰瘍或跛行，請立即聯繫您的獸醫。 - **懷孕警告**：孕婦、哺乳期婦女及準備懷孕的人士應避免接觸此藥物。
丙卡巴肼對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。