Procarbazine
別名: Matulane, Natulan, Natulanar
> **CRITICAL SAFETY WARNING**: Procarbazine is a chemotherapy drug. Strict safety measures must be taken at home to protect human family members. - **Safe Handling**: Always wear disposable gloves when handling this medication. Wash your hands thoroughly after giving the dose. - **Waste Management**: Avoid direct contact with your pet's saliva, vomit, urine, or feces for several days after administration. Clean up accidents wearing gloves and dispose of waste in sealed plastic bags. - **When to Call the Vet**: Contact your veterinarian immediately if your pet shows signs of toxicity, including vomiting, lack of appetite, diarrhea, abnormal bleeding or bruising, severe depression, agitation, sores in the mouth, or lameness. - **Pregnancy Warning**: Pregnant women, nursing mothers, and individuals trying to conceive should not handle this medication.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- MOPP lymphoma rescue
- Lymphoma rescue (MOPP protocol)
- Granulomatous meningoencephalitis (GME)
給藥方式
可能的副作用
- Nausea and vomiting
- Hepatotoxicity
- Myelosuppression (thrombocytopenia, leukopenia)
- Hemorrhagic gastritis
- CNS effects (sedation, agitation)
- Peripheral neuropathy (loss of tendon reflexes, paresthesias, myalgia)
注意事項與禁忌
- Known hypersensitivity to procarbazine
- Inadequate bone marrow reserve
- > **Hazardous Drug**: Procarbazine is a cytotoxic agent and a known teratogen (FDA Category D). Strict safe handling protocols must be followed by both veterinary staff and pet owners. - Use with extreme caution in patients with impaired **renal or hepatic function**. - Use with extreme caution when co-administering with other **CNS depressant drugs**. - Because it is often used in combination protocols (e.g., MOPP), myelosuppression and GI effects may be significantly enhanced.
藥物相互作用
- Alcohol/Ethanol: May cause severe nausea and vomiting (disulfiram-like reaction).
- CNS Depressant Drugs (barbiturates, opiates, antihistamines, phenothiazines): Procarbazine can cause CNS depression; concurrent use can lead to severe depression. Coma and death have been reported with opiates.
- Foods with high tyramine content (aged cheese, yogurt): Serious hypertension may result due to procarbazine's MAOI activity.
- Sympathomimetics (phenylpropanolamine, etc.): Serious hypertension may result due to procarbazine's MAOI activity.
- Tricyclic Antidepressants (clomipramine, amitriptyline): Do not use concurrently due to MAOI activity; risk of serotonin syndrome or hypertensive crisis.
常見問題
Procarbazine用於寵物有甚麼用途？
> **CRITICAL SAFETY WARNING**: Procarbazine is a chemotherapy drug. Strict safety measures must be taken at home to protect human family members. - **Safe Handling**: Always wear disposable gloves when handling this medication. Wash your hands thoroughly after giving the dose. - **Waste Management**: Avoid direct contact with your pet's saliva, vomit, urine, or feces for several days after administration. Clean up accidents wearing gloves and dispose of waste in sealed plastic bags. - **When to Call the Vet**: Contact your veterinarian immediately if your pet shows signs of toxicity, including vomiting, lack of appetite, diarrhea, abnormal bleeding or bruising, severe depression, agitation, sores in the mouth, or lameness. - **Pregnancy Warning**: Pregnant women, nursing mothers, and individuals trying to conceive should not handle this medication.
Procarbazine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。