溴化鉀

用途

• Control of seizures (Maintenance)
• Control of seizures (5-day Loading Dose)
• Control of seizures (Single Loading Dose)
• Control of seizures (Intrarectal Loading)
• Contraindicated

給藥方式

可能的副作用

• Ataxia
• Sedation
• Somnolence
• Vomiting (especially with high concentration solutions >250 mg/ml)
• Polyphagia
• Polydipsia
• Pancreatitis
• Skin reactions (in animals with pre-existing skin diseases)
• Behavioural changes (irritability, restlessness)
• Transient diarrhoea (with intrarectal loading)

注意事項與禁忌

• Cats (causes severe, potentially fatal eosinophilic bronchitis)
• Dogs with a history of, or predisposition to, pancreatitis
• > **Dietary Consistency:** High levels of dietary salt increase renal elimination of bromide. It is critical that the patient's diet (including treats) be kept strictly constant once bromide therapy has started. > **Laboratory Artifact:** Bromide is measured in assays for chloride and will produce falsely high 'chloride' results. > **Renal Impairment:** Use with caution in dogs with renal disease, as bromide is eliminated by the kidneys. > **Loading Dose Risks:** Loading doses are associated with an increased incidence of adverse effects (sedation, ataxia) and should only be used in dogs with poorly controlled severe seizures.

藥物相互作用

• Dietary salt (Sodium chloride): Increased dietary salt increases renal elimination of bromide, decreasing serum bromide concentrations.
• Chloride-containing IV fluids: Increases bromide excretion and lowers serum bromide levels.
• Loop diuretics (e.g., furosemide): Increases bromide excretion and decreases serum bromide concentrations.
• Phenobarbital: Synergistic GABA-ergic anticonvulsant effects.

常見問題