硝酸甘油

用途

• Adjunctive treatment of heart failure (severe pulmonary edema secondary to HCM)
• To enhance resolution of pulmonary edema
• Adjunctive treatment of heart failure
• Adjunctive treatment of pulmonary edema
• Cardiogenic pulmonary edema (headed for oxygen)
• Adjunctive treatment of hypertension
• Adjunctive therapy for heart failure
• Dilative cardiomyopathy
• Adjunctive treatment of heart failure
• Adjunctive treatment of heart failure
• Adjunctive treatment of pulmonary edema
• Cardiogenic pulmonary edema (headed for oxygen)
• Venodilator for adjunctive treatment of systolic heart failure

給藥方式

可能的副作用

• Rashes or erythema at the application site
• Orthostatic hypotension
• Transient headaches (common in humans, suspected in animals)
• Lethargy or weakness secondary to hypotension

注意事項與禁忌

• Severe anemia
• Hypersensitivity to nitrates
• ### Important Warnings * **Hypotension Risk**: Use with extreme caution (if at all) in patients with diuretic-induced hypovolemia, cerebral hemorrhage, head trauma, or other hypotensive conditions. * **Tolerance**: Continuous use (48-72 hours) results in the rapid development of tolerance to the drug's effects. Intermittent dosing is recommended. * **Human Exposure**: Personnel applying the drug **must wear non-permeable gloves** to prevent self-absorption, which can cause severe headaches and hypotension. * **Pregnancy**: FDA Category C. Use cautiously as a last resort when the benefit clearly outweighs the risks. Unknown if excreted in maternal milk; use with caution in nursing animals.

藥物相互作用

• Antihypertensive drugs: Use of nitroglycerin with other antihypertensive drugs may cause additive hypotensive effects.
• Phenothiazines: May increase hypotensive effects.
• Sildenafil (and other PDE inhibitors): May profoundly increase risk for severe, potentially fatal hypotension.

常見問題