米索前列醇

用途

• Induction of abortion
• Adjunctive treatment of acute colitis
• Equine gastric ulcer syndrome
• Induce cervical relaxation (post-breeding endometritis)
• Prevention of aspirin-induced gastric injury
• Prevention or treatment of gastric ulceration from NSAIDs
• Prevention or treatment of gastric ulceration from NSAIDs
• Preventing GI mucosal injury in dogs with arthritis requiring long-term NSAID therapy; treating gastro-duodenal ulcer disease caused by NSAIDS
• Adjunctive therapy for the termination of mid-term pregnancy
• Treating pyometra/metritis
• Abortifacient protocol after mismating
• Adjunctive therapy for atopic dermatitis

給藥方式

可能的副作用

• Diarrhea
• Abdominal pain
• Vomiting
• Flatulence
• Uterine contractions (in females)
• Vaginal bleeding (in females)
• Diarrhoea
• Nausea
• Abortion

注意事項與禁忌

• Pregnancy (unless being used specifically as an abortifacient)
• Nursing mothers (can cause severe diarrhea in nursing offspring)
• Known sensitivity to prostaglandins or prostaglandin analogs
• Pregnant animals (unless being used specifically to induce abortion)
• > **WARNING FOR PREGNANT WOMEN**: Misoprostol is a potent abortifacient. Pregnant women or women who may become pregnant should handle this drug with extreme caution (e.g., wearing gloves or avoiding handling altogether). * Use with caution in patients with **cerebral or coronary vascular disease**. While not explicitly reported with misoprostol, other prostaglandins have precipitated seizures in epileptic patients and caused hypotension. * Adverse GI effects are common but often transient; they can be minimized by adjusting the dose or administering the drug with food.

藥物相互作用

• Magnesium-containing antacids: May aggravate misoprostol-induced diarrhea. If an antacid is required, an aluminum-only antacid is preferred.
• Gentamicin: May exacerbate renal dysfunction
• Diclofenac: Human combination products (misoprostol + diclofenac) are highly toxic to small animals due to different NSAID pharmacokinetics

常見問題