Misoprostol
別名: Cytotec, Arthotec, Arthrotec, Artotec, Artrenac Pro, Condrotec, Corrigast, Cyprostol, Cytolog, Diclotec, Glefos, Menpros, Misodex, Misofenac, Napratec, Normulen, Oxaprost, Symbol
> **CRITICAL WARNING FOR PREGNANT WOMEN**: This medication can cause uterine contractions and miscarriage. Pregnant women, or women trying to conceive, should **not** handle this medication. If handling is absolutely necessary, strict precautions (such as wearing disposable gloves) must be taken. * **Gastrointestinal Upset**: The most common side effects are diarrhea, abdominal cramping, and vomiting. These are often temporary and resolve over a few days as your pet's body adjusts to the medication. * **Administration**: Giving this medication with food can help minimize stomach upset and diarrhea. * **When to Call the Vet**: If diarrhea becomes severe, persists for more than a few days, or if your pet becomes lethargic, contact your veterinarian. They may need to adjust the dose or recommend a specific antacid (avoid magnesium-containing antacids as they worsen diarrhea). * **Female Pets**: If given to an intact female dog, you may notice vaginal bleeding or discharge due to the drug's effect on the uterus.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Induction of abortion
- Adjunctive treatment of acute colitis
- Equine gastric ulcer syndrome
- Induce cervical relaxation (post-breeding endometritis)
- Prevention of aspirin-induced gastric injury
- Prevention or treatment of gastric ulceration from NSAIDs
- Prevention or treatment of gastric ulceration from NSAIDs
- Preventing GI mucosal injury in dogs with arthritis requiring long-term NSAID therapy; treating gastro-duodenal ulcer disease caused by NSAIDS
- Adjunctive therapy for the termination of mid-term pregnancy
- Treating pyometra/metritis
- Abortifacient protocol after mismating
- Adjunctive therapy for atopic dermatitis
給藥方式
可能的副作用
- Diarrhea
- Abdominal pain
- Vomiting
- Flatulence
- Uterine contractions (in females)
- Vaginal bleeding (in females)
- Diarrhoea
- Nausea
- Abortion
注意事項與禁忌
- Pregnancy (unless being used specifically as an abortifacient)
- Nursing mothers (can cause severe diarrhea in nursing offspring)
- Known sensitivity to prostaglandins or prostaglandin analogs
- Pregnant animals (unless being used specifically to induce abortion)
- > **WARNING FOR PREGNANT WOMEN**: Misoprostol is a potent abortifacient. Pregnant women or women who may become pregnant should handle this drug with extreme caution (e.g., wearing gloves or avoiding handling altogether). * Use with caution in patients with **cerebral or coronary vascular disease**. While not explicitly reported with misoprostol, other prostaglandins have precipitated seizures in epileptic patients and caused hypotension. * Adverse GI effects are common but often transient; they can be minimized by adjusting the dose or administering the drug with food.
藥物相互作用
- Magnesium-containing antacids: May aggravate misoprostol-induced diarrhea. If an antacid is required, an aluminum-only antacid is preferred.
- Gentamicin: May exacerbate renal dysfunction
- Diclofenac: Human combination products (misoprostol + diclofenac) are highly toxic to small animals due to different NSAID pharmacokinetics
常見問題
Misoprostol用於寵物有甚麼用途？
> **CRITICAL WARNING FOR PREGNANT WOMEN**: This medication can cause uterine contractions and miscarriage. Pregnant women, or women trying to conceive, should **not** handle this medication. If handling is absolutely necessary, strict precautions (such as wearing disposable gloves) must be taken. * **Gastrointestinal Upset**: The most common side effects are diarrhea, abdominal cramping, and vomiting. These are often temporary and resolve over a few days as your pet's body adjusts to the medication. * **Administration**: Giving this medication with food can help minimize stomach upset and diarrhea. * **When to Call the Vet**: If diarrhea becomes severe, persists for more than a few days, or if your pet becomes lethargic, contact your veterinarian. They may need to adjust the dose or recommend a specific antacid (avoid magnesium-containing antacids as they worsen diarrhea). * **Female Pets**: If given to an intact female dog, you may notice vaginal bleeding or discharge due to the drug's effect on the uterus.
Misoprostol對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。