美羅培南

用途

• Pharmacokinetic data
• Bacteremia/sepsis
• UTI
• CNS infections
• Systemic infections
• Urinary tract infections
• Susceptible infections
• Susceptible infections
• Bacteremia/sepsis
• UTI
• CNS infections
• Systemic infections
• Urinary tract infections
• Susceptible infections (Small dogs)

給藥方式

可能的副作用

• Slight hair loss over SC injection sites
• Nausea (reported in humans)
• Vomiting (reported in humans)
• Diarrhea (reported in humans)

注意事項與禁忌

• Hypersensitivity to meropenem or other carbapenems
• History of anaphylaxis after receiving any beta-lactam antibiotic
• **Warnings and Precautions:** * **Antimicrobial Stewardship:** Use should be limited or avoided unless absolutely necessary to prevent the development of resistant bacterial strains that might infect humans. * **Hypersensitivity:** Use with caution in patients with known allergies to penicillins or cephalosporins due to potential cross-reactivity. * **Pregnancy/Lactation:** FDA Category B in humans (likely safe). It is considered likely safe to use during lactation. * **Renal Impairment:** While safer than aminoglycosides, dosage adjustments (e.g., extending the dosing interval) may be necessary in severe renal failure (e.g., serum creatinine > 4 mg/dL).

藥物相互作用

• Aminoglycosides: In vitro evidence of synergy against Pseudomonas aeruginosa
• Probenecid: May increase serum concentrations and elimination half-life of meropenem

常見問題