美拉索明

用途

• Heartworm disease (Class I & II)
• Heartworm disease (Class III)
• Heartworm disease (Alternative Protocol / AHS Treatment of Choice)

給藥方式

可能的副作用

• Injection site reactions (pain, swelling, tenderness, firm nodules)
• Coughing/gagging
• Depression/lethargy
• Anorexia/inappetence
• Excessive salivation
• Fever
• Lung congestion
• Vomiting
• Pulmonary thromboembolism (can be fatal)
• Paresis and paralysis (rare)

注意事項與禁忌

• Class IV (very severe) heartworm disease / Caval syndrome
• Cats (reportedly very toxic)
• Intravenous (IV) administration
• Subcutaneous (SC) administration
• Low margin of safety; calculate dosages very carefully (do not confuse mg/lb with mg/kg). Administer ONLY via deep IM injection in the lumbar epaxial muscles (L3-L5). Do NOT give IV or SC, as significant toxicity or tissue necrosis may occur. Strict cage rest (2-4 weeks) is mandatory to prevent fatal pulmonary thromboembolism. Older dogs (>8 years) and those with severe pulmonary artery disease are at higher risk for adverse effects. Avoid human exposure; wash hands after use or wear gloves. If human exposure occurs, contact a physician.

藥物相互作用

• Aspirin: Has been shown not to reduce adverse effects and may complicate therapy; use is not recommended.
• CNS Depressant Drugs: Drugs that have similar adverse effects (e.g., depression) may cause additive adverse effects or increase their incidence when used with melarsomine.

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