灰黃黴素

用途

• Susceptible dermatophytic infections
• Susceptible dermatophytic infections
• Susceptible dermatophytic infections
• Feline eosinophilic granuloma complex
• Susceptible dermatophytic infections
• Susceptible dermatophytic infections
• Susceptible dermatophytic infections
• Susceptible dermatophytic infections (Ratites)
• Susceptible dermatophytic infections
• Advanced dermatophytosis (Rabbits)
• Susceptible dermatophytic infections (Chinchillas)
• Susceptible dermatophytic infections (Gerbils, Guinea pigs, Hamsters, Rats)
• Susceptible dermatophytic infections (Mice)

給藥方式

可能的副作用

• Anorexia
• Vomiting
• Diarrhea
• Anemia
• Neutropenia
• Leukopenia
• Thrombocytopenia
• Depression
• Ataxia
• Hepatotoxicity
• Dermatitis/photosensitivity
• Toxic epidermal necrolysis
• Teratogenesis

注意事項與禁忌

• Pregnancy (known teratogen)
• Known hypersensitivity to griseofulvin
• Hepatocellular failure
• Horses intended for food
• **Important Warnings:** * **Feline Sensitivity:** Cats, particularly kittens, are highly susceptible to adverse effects (e.g., bone marrow depression), likely due to slower glucuronide conjugation. Monitor carefully. * **FIV Testing:** Cats should be tested for FIV before initiating therapy due to the drug's potential neutropenic or panleukopenic effects. * **Teratogenicity:** Griseofulvin is a known teratogen (causes cleft palate, skeletal/brain malformations). It is strictly contraindicated in pregnant animals. It may also inhibit spermatogenesis. * **Absorption:** Must be given with a fatty meal to ensure adequate GI absorption.

藥物相互作用

• Alcohol: Griseofulvin may potentiate the effects of alcohol.
• Aspirin: Griseofulvin may decrease salicylate levels.
• Cyclosporine: Griseofulvin may decrease cyclosporine levels.
• Phenobarbital: May decrease griseofulvin blood concentrations by inducing hepatic microsomal enzymes and/or reducing absorption. Dosage adjustment may be necessary.
• Theophylline: May decrease theophylline half-life and levels in some patients.
• Warfarin: May reduce the anticoagulant activity of coumarin anticoagulants; adjustment may be required.

常見問題