氟西汀
別名: Prozac, Reconcile, Sarafem
- **耐心是關鍵:** 此藥物通常需要 4 到 8 週才能發揮最大效用。請勿因為沒有立即看到效果就停止給藥。 - **行為矯正:** 當與獸醫師建議的行為矯正和訓練計畫結合使用時,氟西汀的效果最佳。 - **副作用:** 最常見的副作用包括嗜睡、食慾不振、嘔吐、發抖、焦躁不安、腹瀉和過度鳴叫。如果這些症狀嚴重或持續存在,請聯繫您的獸醫師。 - **食慾減退:** 如果您的寵物食慾下降,可以嘗試親手餵食或暫時增加食物的適口性(例如添加少量濕糧或低鈉肉湯)。 - **請勿突然停藥:** 未經獸醫師指導,請勿突然停止使用此藥物,因為這可能會導致戒斷症狀或行為復發。 - **癲癇警告:** 極少數情況下,犬隻在服用此藥物期間可能會出現癲癇發作。如果發生癲癇,請立即聯繫獸醫師。 - **防壁蝨項圈:** 如果您使用防壁蝨項圈,請告知獸醫師,因為某些項圈含有雙甲脒 (amitraz),與氟西汀結合使用時會引起危險的藥物交互作用(血清素症候群)。 - 請將此藥物存放在兒童和其他寵物接觸不到的安全地方。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive treatment of aggression
- To help control urine marking or separation anxiety
- To control pruritus when other therapies have failed
- Generalized anxiety disorder
- Urine spraying, psychogenic alopecia, and aggression
- Treatment of canine separation anxiety in conjunction with a behavior modification plan
- Separation anxiety and noise aversions
- Adjunctive pharmacological intervention for conflict-related aggression
- Compulsive disorders
- Adjunctive treatment of behavior disorders
- Adjunctive treatment of behavior disorders
- Separation anxiety, compulsive disorders, and aggression
給藥方式
可能的副作用
- Anorexia or decreased appetite (common, often transient)
- Lethargy or depression
- Gastrointestinal upset (vomiting, diarrhea)
- Anxiety, irritability, or restlessness
- Insomnia or hyperactivity
- Panting (dogs)
- Changes in elimination patterns (cats)
- Paradoxical aggressive behavior (in previously unaggressive animals)
- Seizures (rare but possible)
- Lethargy
- Decreased appetite
- Vomiting
- Weight loss
- Trembling
注意事項與禁忌
- Known hypersensitivity to fluoxetine
- Concurrent use of Monoamine Oxidase Inhibitors (MAOIs), including selegiline and amitraz (found in some tick collars)
- Patients with epilepsy or a history of seizures
- Concurrent use with drugs that lower the seizure threshold (e.g., acepromazine, chlorpromazine)
- Known sensitivity to fluoxetine or other SSRIs
- History of seizures or epilepsy
- - **Seizure Disorders:** Use is contraindicated in patients with a history of seizures. - **Diabetes Mellitus:** Use with caution as fluoxetine may alter blood glucose levels, necessitating insulin adjustments. - **Hepatic Impairment:** Dosages may need to be reduced in patients with severe liver disease due to decreased clearance. - **Tapering:** Because of the long half-life of the active metabolite (norfluoxetine), tapering off the drug is generally only necessary when a patient has been on the drug long-term (>8 weeks). - **Pregnancy/Nursing:** Safety is not fully established (FDA Category C in humans). Excreted in milk at 20-30% of plasma levels; use caution in nursing animals.
藥物相互作用
- BUSPIRONE: Increased risk for serotonin syndrome
- CYPROHEPTADINE: May decrease or reverse the effects of SSRIs (acts as a serotonin antagonist)
- DIAZEPAM, ALPRAZOLAM: Fluoxetine may increase diazepam and alprazolam plasma levels
- DIURETICS: Increased risk for hyponatremia
- INSULIN: May alter insulin requirements (can alter blood glucose)
- ISONIAZID: Increased risk for serotonin syndrome
- MAO INHIBITORS (e.g., amitraz, selegiline): High risk for serotonin syndrome; use contraindicated. A 5-week washout is required after stopping fluoxetine before starting an MAOI, and a 2-week washout if switching from an MAOI to fluoxetine.
- PENTAZOCINE: Serotonin syndrome-like adverse effects possible
- PHENYTOIN: Increased plasma levels of phenytoin possible
- PROPRANOLOL, METOPROLOL: Fluoxetine may increase these beta-blocker's plasma levels; atenolol may be safer to use
- TRAMADOL: SSRIs can inhibit the metabolism of tramadol to active metabolites, decreasing efficacy and increasing toxicity risk (serotonin syndrome, seizures)
常見問題
氟西汀用於寵物有什麼用途?
- **耐心是關鍵:** 此藥物通常需要 4 到 8 週才能發揮最大效用。請勿因為沒有立即看到效果就停止給藥。 - **行為矯正:** 當與獸醫師建議的行為矯正和訓練計畫結合使用時,氟西汀的效果最佳。 - **副作用:** 最常見的副作用包括嗜睡、食慾不振、嘔吐、發抖、焦躁不安、腹瀉和過度鳴叫。如果這些症狀嚴重或持續存在,請聯繫您的獸醫師。 - **食慾減退:** 如果您的寵物食慾下降,可以嘗試親手餵食或暫時增加食物的適口性(例如添加少量濕糧或低鈉肉湯)。 - **請勿突然停藥:** 未經獸醫師指導,請勿突然停止使用此藥物,因為這可能會導致戒斷症狀或行為復發。 - **癲癇警告:** 極少數情況下,犬隻在服用此藥物期間可能會出現癲癇發作。如果發生癲癇,請立即聯繫獸醫師。 - **防壁蝨項圈:** 如果您使用防壁蝨項圈,請告知獸醫師,因為某些項圈含有雙甲脒 (amitraz),與氟西汀結合使用時會引起危險的藥物交互作用(血清素症候群)。 - 請將此藥物存放在兒童和其他寵物接觸不到的安全地方。
氟西汀對我的寵物安全嗎?
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育,不能取代專業獸醫意見。如寵物身體不適,請諮詢獸醫。