Fluoxetine
別名: Prozac, Reconcile, Sarafem
- **Patience is Key:** This medication often takes 4 to 8 weeks to show its full effect. Do not stop giving it just because you don't see immediate results. - **Behavior Modification:** Fluoxetine is most effective when used alongside a behavior modification and training program recommended by your veterinarian. - **Side Effects:** The most common side effects include lethargy, decreased appetite, vomiting, shaking, restlessness, diarrhea, and excessive whining. If these are severe or persist, contact your veterinarian. - **Appetite Loss:** If your pet loses their appetite, try hand-feeding or temporarily increasing the palatability of their food (e.g., adding a little wet food or low-sodium broth). - **Do Not Stop Abruptly:** Do not discontinue this medication suddenly without your veterinarian's guidance, as it may cause withdrawal-like signs or a relapse in behavior. - **Seizure Warning:** Rarely, dogs may develop seizures while on this medication. If a seizure occurs, contact your veterinarian immediately. - **Tick Collars:** Inform your veterinarian if you use tick collars, as some contain amitraz, which can cause a dangerous drug interaction (serotonin syndrome) when combined with fluoxetine. - Keep this medication safely out of reach of children and other pets.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Adjunctive treatment of aggression
- To help control urine marking or separation anxiety
- To control pruritus when other therapies have failed
- Generalized anxiety disorder
- Urine spraying, psychogenic alopecia, and aggression
- Treatment of canine separation anxiety in conjunction with a behavior modification plan
- Separation anxiety and noise aversions
- Adjunctive pharmacological intervention for conflict-related aggression
- Compulsive disorders
- Adjunctive treatment of behavior disorders
- Adjunctive treatment of behavior disorders
- Separation anxiety, compulsive disorders, and aggression
給藥方式
可能的副作用
- Anorexia or decreased appetite (common, often transient)
- Lethargy or depression
- Gastrointestinal upset (vomiting, diarrhea)
- Anxiety, irritability, or restlessness
- Insomnia or hyperactivity
- Panting (dogs)
- Changes in elimination patterns (cats)
- Paradoxical aggressive behavior (in previously unaggressive animals)
- Seizures (rare but possible)
- Lethargy
- Decreased appetite
- Vomiting
- Weight loss
- Trembling
注意事項與禁忌
- Known hypersensitivity to fluoxetine
- Concurrent use of Monoamine Oxidase Inhibitors (MAOIs), including selegiline and amitraz (found in some tick collars)
- Patients with epilepsy or a history of seizures
- Concurrent use with drugs that lower the seizure threshold (e.g., acepromazine, chlorpromazine)
- Known sensitivity to fluoxetine or other SSRIs
- History of seizures or epilepsy
- - **Seizure Disorders:** Use is contraindicated in patients with a history of seizures. - **Diabetes Mellitus:** Use with caution as fluoxetine may alter blood glucose levels, necessitating insulin adjustments. - **Hepatic Impairment:** Dosages may need to be reduced in patients with severe liver disease due to decreased clearance. - **Tapering:** Because of the long half-life of the active metabolite (norfluoxetine), tapering off the drug is generally only necessary when a patient has been on the drug long-term (>8 weeks). - **Pregnancy/Nursing:** Safety is not fully established (FDA Category C in humans). Excreted in milk at 20-30% of plasma levels; use caution in nursing animals.
藥物相互作用
- BUSPIRONE: Increased risk for serotonin syndrome
- CYPROHEPTADINE: May decrease or reverse the effects of SSRIs (acts as a serotonin antagonist)
- DIAZEPAM, ALPRAZOLAM: Fluoxetine may increase diazepam and alprazolam plasma levels
- DIURETICS: Increased risk for hyponatremia
- INSULIN: May alter insulin requirements (can alter blood glucose)
- ISONIAZID: Increased risk for serotonin syndrome
- MAO INHIBITORS (e.g., amitraz, selegiline): High risk for serotonin syndrome; use contraindicated. A 5-week washout is required after stopping fluoxetine before starting an MAOI, and a 2-week washout if switching from an MAOI to fluoxetine.
- PENTAZOCINE: Serotonin syndrome-like adverse effects possible
- PHENYTOIN: Increased plasma levels of phenytoin possible
- PROPRANOLOL, METOPROLOL: Fluoxetine may increase these beta-blocker's plasma levels; atenolol may be safer to use
- TRAMADOL: SSRIs can inhibit the metabolism of tramadol to active metabolites, decreasing efficacy and increasing toxicity risk (serotonin syndrome, seizures)
常見問題
Fluoxetine用於寵物有甚麼用途？
- **Patience is Key:** This medication often takes 4 to 8 weeks to show its full effect. Do not stop giving it just because you don't see immediate results. - **Behavior Modification:** Fluoxetine is most effective when used alongside a behavior modification and training program recommended by your veterinarian. - **Side Effects:** The most common side effects include lethargy, decreased appetite, vomiting, shaking, restlessness, diarrhea, and excessive whining. If these are severe or persist, contact your veterinarian. - **Appetite Loss:** If your pet loses their appetite, try hand-feeding or temporarily increasing the palatability of their food (e.g., adding a little wet food or low-sodium broth). - **Do Not Stop Abruptly:** Do not discontinue this medication suddenly without your veterinarian's guidance, as it may cause withdrawal-like signs or a relapse in behavior. - **Seizure Warning:** Rarely, dogs may develop seizures while on this medication. If a seizure occurs, contact your veterinarian immediately. - **Tick Collars:** Inform your veterinarian if you use tick collars, as some contain amitraz, which can cause a dangerous drug interaction (serotonin syndrome) when combined with fluoxetine. - Keep this medication safely out of reach of children and other pets.
Fluoxetine對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。