依地酸鈣鈉 (CaEDTA)

用途

• Lead poisoning (Psittacines)
• Lead poisoning (Raptors/Falcons)
• Lead or zinc poisoning
• Lead poisoning
• Lead poisoning
• Lead poisoning
• Zinc toxicity
• Lead or zinc toxicity
• Heavy metal toxicity (Chinchillas)
• Lead poisoning
• Lead or zinc toxicity
• Lead poisoning
• Lead poisoning
• Lead poisoning

給藥方式

可能的副作用

• Renal toxicity (renal tubular necrosis)
• Depression (dogs)
• Vomiting
• Diarrhea
• Zinc deficiency (with chronic therapy)
• Pain at IM injection site

注意事項與禁忌

• Patients with anuria
• Oral (PO) administration in the presence of lead in the GI tract (enhances absorption)
• Use with **extreme caution** in patients with diminished renal function; dosage adjustments are required. In small animals, the **SC route is strongly preferred**. IV administration has been associated with abrupt increases in CSF pressure and death in human pediatric patients with lead-induced cerebral edema. **Do not administer orally** if lead is still present in the GI tract, as it will facilitate systemic absorption of the lead. Remove lead from the GI tract (via emesis, endoscopy, or surgery) prior to starting chelation. Ensure adequate hydration to protect the kidneys, but avoid overhydration in animals showing clinical signs of cerebral edema.

藥物相互作用

• Glucocorticoids: May enhance the renal toxicity of CaEDTA
• Insulin (NPH, PZI): Concurrent administration will decrease the sustained action of the insulin preparation due to zinc chelation
• Nephrotoxic drugs (e.g., aminoglycosides, amphotericin B): Increased risk of nephrotoxicity; use with extreme caution

常見問題