雙氫速甾醇
別名: DHT, Hytakerol, AT 10, Atiten, Dihydral, Dygratyl, Tachyrol, Tachystin
### 寵物主人重要須知 **雙氫速甾醇 (DHT)** 是一種幫助您的寵物身體吸收和維持正常鈣水平的藥物，通常是因為牠們的甲狀旁腺或腎臟功能不全。 * **嚴格給藥**：請完全按照處方給藥。未經獸醫明確指示，**絕對不要**改變劑量或給予額外的鈣補充劑。即使是微小的改變也可能導致血鈣水平發生危險的波動。 * **高血鈣的徵兆**：密切注意寵物是否出現口渴增加（喝更多水）、排尿增加、食慾不振、嘔吐或嚴重嗜睡。如果您注意到這些跡象，請立即聯繫您的獸醫。 * **低血鈣的徵兆**：如果劑量太低，您的寵物可能會出現低血鈣的跡象，包括肌肉顫抖、面部抽搐、僵硬、虛弱、行走不協調（共濟失調）、行為改變或癲癇發作。 * **頻繁的血液檢查**：您的寵物將需要頻繁的血液檢查，特別是在開始服藥時，以確保牠們的鈣水平處於安全範圍。這對牠們的安全是強制性的。 * **給藥方式**：如果您的寵物對藥丸反應不佳，獸醫可能會將其改為液體形式，有時液體的吸收效果更好。
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Hypocalcemia secondary to hypoparathyroidism
- Chronic hypocalcemia with oral calcium tx
- Hypocalcemia secondary to hypoparathyroidism
給藥方式
可能的副作用
- Hypercalcemia (manifesting as polydipsia, polyuria, anorexia, vomiting, lethargy)
- Nephrocalcinosis (soft tissue mineralization)
- Hyperphosphatemia
注意事項與禁忌
- Pre-existing hypercalcemia
- Vitamin D toxicity
- Malabsorption syndromes
- Abnormal sensitivity to the effects of vitamin D
- ### Important Warnings * **Hyperphosphatemia**: Use with extreme caution. Many clinicians consider hyperphosphatemia or a combined calcium/phosphorus product of >70 mg/dL to be an absolute contraindication due to the risk of metastatic soft tissue mineralization (nephrocalcinosis). * **Renal Dysfunction**: Use with extreme caution when receiving the drug for non-renal indications. * **Pregnancy**: FDA Category C. Hypervitaminosis D has caused fetal abnormalities in various species. Weigh risks vs. benefits. * **Nursing**: Vitamin D is excreted in breast milk in limited amounts; use with caution. * **Laboratory Interference**: Serum cholesterol levels may be falsely elevated by vitamin D analogs when using the Zlatkis-Zak reaction.
藥物相互作用
- Calcium-containing phosphorus binding agents (e.g., calcium carbonate): Use with vitamin D analogs may induce severe hypercalcemia.
- Corticosteroids: Can nullify the calcium-elevating effects of vitamin D analogs.
- Digoxin: Patients are highly sensitive to the arrhythmogenic effects of hypercalcemia; intensified monitoring is required.
- Verapamil: Patients are sensitive to the effects of hypercalcemia; intensified monitoring is required.
- Mineral oil: May reduce the amount of DHT absorbed from the GI tract.
- Sucralfate: May reduce the amount of DHT absorbed from the GI tract.
- Cholestyramine: May reduce the amount of DHT absorbed from the GI tract.
- Phenytoin: May induce hepatic enzyme systems and increase the metabolism of Vitamin D analogs, thus decreasing their activity.
- Barbiturates: May induce hepatic enzyme systems and increase the metabolism of Vitamin D analogs, thus decreasing their activity.
- Primidone: May induce hepatic enzyme systems and increase the metabolism of Vitamin D analogs, thus decreasing their activity.
常見問題
雙氫速甾醇用於寵物有什麼用途？
### 寵物主人重要須知 **雙氫速甾醇 (DHT)** 是一種幫助您的寵物身體吸收和維持正常鈣水平的藥物，通常是因為牠們的甲狀旁腺或腎臟功能不全。 * **嚴格給藥**：請完全按照處方給藥。未經獸醫明確指示，**絕對不要**改變劑量或給予額外的鈣補充劑。即使是微小的改變也可能導致血鈣水平發生危險的波動。 * **高血鈣的徵兆**：密切注意寵物是否出現口渴增加（喝更多水）、排尿增加、食慾不振、嘔吐或嚴重嗜睡。如果您注意到這些跡象，請立即聯繫您的獸醫。 * **低血鈣的徵兆**：如果劑量太低，您的寵物可能會出現低血鈣的跡象，包括肌肉顫抖、面部抽搐、僵硬、虛弱、行走不協調（共濟失調）、行為改變或癲癇發作。 * **頻繁的血液檢查**：您的寵物將需要頻繁的血液檢查，特別是在開始服藥時，以確保牠們的鈣水平處於安全範圍。這對牠們的安全是強制性的。 * **給藥方式**：如果您的寵物對藥丸反應不佳，獸醫可能會將其改為液體形式，有時液體的吸收效果更好。
雙氫速甾醇對我的寵物安全嗎？
劑量必須由獸醫依你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。