Dihydrotachysterol
別名: DHT, Hytakerol, AT 10, Atiten, Dihydral, Dygratyl, Tachyrol, Tachystin
### Important Information for Pet Owners **Dihydrotachysterol (DHT)** is a medication used to help your pet's body absorb and maintain normal levels of calcium, usually because their parathyroid glands or kidneys are not functioning properly. * **Strict Dosing**: Give this medication exactly as prescribed. **Never** change the dose or give extra calcium supplements without explicit instructions from your veterinarian. Even small changes can cause dangerous shifts in blood calcium levels. * **Signs of High Calcium (Hypercalcemia)**: Watch closely for increased thirst (drinking more water), increased urination, loss of appetite, vomiting, or severe lethargy. Contact your vet immediately if you notice these signs. * **Signs of Low Calcium (Hypocalcemia)**: If the dose is too low, your pet may show signs of low calcium, including muscle tremors, facial twitching, stiffness, weakness, uncoordinated walking (ataxia), behavioral changes, or seizures. * **Frequent Blood Tests**: Your pet will need frequent blood tests, especially when starting the medication, to ensure their calcium levels are safe. This is mandatory for their safety. * **Administration**: If your pet is not responding well to pills, your vet may switch them to a liquid form, which is sometimes absorbed better.
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
用途
- Hypocalcemia secondary to hypoparathyroidism
- Chronic hypocalcemia with oral calcium tx
- Hypocalcemia secondary to hypoparathyroidism
給藥方式
可能的副作用
- Hypercalcemia (manifesting as polydipsia, polyuria, anorexia, vomiting, lethargy)
- Nephrocalcinosis (soft tissue mineralization)
- Hyperphosphatemia
注意事項與禁忌
- Pre-existing hypercalcemia
- Vitamin D toxicity
- Malabsorption syndromes
- Abnormal sensitivity to the effects of vitamin D
- ### Important Warnings * **Hyperphosphatemia**: Use with extreme caution. Many clinicians consider hyperphosphatemia or a combined calcium/phosphorus product of >70 mg/dL to be an absolute contraindication due to the risk of metastatic soft tissue mineralization (nephrocalcinosis). * **Renal Dysfunction**: Use with extreme caution when receiving the drug for non-renal indications. * **Pregnancy**: FDA Category C. Hypervitaminosis D has caused fetal abnormalities in various species. Weigh risks vs. benefits. * **Nursing**: Vitamin D is excreted in breast milk in limited amounts; use with caution. * **Laboratory Interference**: Serum cholesterol levels may be falsely elevated by vitamin D analogs when using the Zlatkis-Zak reaction.
藥物相互作用
- Calcium-containing phosphorus binding agents (e.g., calcium carbonate): Use with vitamin D analogs may induce severe hypercalcemia.
- Corticosteroids: Can nullify the calcium-elevating effects of vitamin D analogs.
- Digoxin: Patients are highly sensitive to the arrhythmogenic effects of hypercalcemia; intensified monitoring is required.
- Verapamil: Patients are sensitive to the effects of hypercalcemia; intensified monitoring is required.
- Mineral oil: May reduce the amount of DHT absorbed from the GI tract.
- Sucralfate: May reduce the amount of DHT absorbed from the GI tract.
- Cholestyramine: May reduce the amount of DHT absorbed from the GI tract.
- Phenytoin: May induce hepatic enzyme systems and increase the metabolism of Vitamin D analogs, thus decreasing their activity.
- Barbiturates: May induce hepatic enzyme systems and increase the metabolism of Vitamin D analogs, thus decreasing their activity.
- Primidone: May induce hepatic enzyme systems and increase the metabolism of Vitamin D analogs, thus decreasing their activity.
常見問題
Dihydrotachysterol用於寵物有甚麼用途？
### Important Information for Pet Owners **Dihydrotachysterol (DHT)** is a medication used to help your pet's body absorb and maintain normal levels of calcium, usually because their parathyroid glands or kidneys are not functioning properly. * **Strict Dosing**: Give this medication exactly as prescribed. **Never** change the dose or give extra calcium supplements without explicit instructions from your veterinarian. Even small changes can cause dangerous shifts in blood calcium levels. * **Signs of High Calcium (Hypercalcemia)**: Watch closely for increased thirst (drinking more water), increased urination, loss of appetite, vomiting, or severe lethargy. Contact your vet immediately if you notice these signs. * **Signs of Low Calcium (Hypocalcemia)**: If the dose is too low, your pet may show signs of low calcium, including muscle tremors, facial twitching, stiffness, weakness, uncoordinated walking (ataxia), behavioral changes, or seizures. * **Frequent Blood Tests**: Your pet will need frequent blood tests, especially when starting the medication, to ensure their calcium levels are safe. This is mandatory for their safety. * **Administration**: If your pet is not responding well to pills, your vet may switch them to a liquid form, which is sometimes absorbed better.
Dihydrotachysterol對我的寵物安全嗎？
劑量必須由獸醫按你寵物的個別情況決定。切勿在沒有獸醫指導下給予人類藥物或其他寵物的處方藥。
本文僅供一般健康教育，不能取代專業獸醫意見。如寵物身體不適，請諮詢獸醫。