頭孢泊肟酯 (Cefpodoxime Proxetil)

用途

• For susceptible skin and soft tissue infections
• Foals (neonates) with bacterial infections
• For susceptible skin infections

給藥方式

可能的副作用

• Inappetence
• Diarrhea
• Vomiting
• Hypersensitivity reactions
• Positive direct Coombs' test
• Blood dyscrasias (rare, following high doses)

注意事項與禁忌

• Hypersensitivity to cefpodoxime or other cephalosporins
• **Renal Impairment**: Because cefpodoxime is excreted by the kidneys, dosages and/or dosage frequency may need to be adjusted in patients with significantly diminished renal function. **Seizure Disorders**: Use with caution in patients with a history of seizure disorders. **Laboratory Interference**: * May cause false-positive urine glucose determinations when using cupric sulfate solution (Benedict's Solution, Clinitest). Glucose oxidase tests are unaffected. * May cause false-positive results in nitroprusside tests for urinary ketones. **Breeding/Pregnancy**: Safety in breeding, pregnant, or lactating dogs has not been demonstrated. Use only when clearly indicated.

藥物相互作用

• Aminoglycosides / Nephrotoxic drugs (e.g., amphotericin B): Potentially additive nephrotoxicity (controversial). In vitro synergy exists, but do not mix together in the same syringe/fluid.
• Antacids: Drugs that increase stomach pH may decrease the absorption of cefpodoxime.
• H-2 Antagonists (ranitidine, famotidine): Drugs that increase stomach pH may decrease the absorption of cefpodoxime.
• Probenecid: Competitively blocks tubular secretion of cephalosporins, increasing serum levels and half-lives.
• Proton Pump Inhibitors (omeprazole): Drugs that increase stomach pH may decrease the absorption of cefpodoxime.

常見問題