門冬醯胺酶

用途

• Lymphoid malignancies / Leukemia
• Treatment of lymphoid malignancies
• Lymphoid malignancies / Leukemia
• Treatment of lymphoid malignancies

給藥方式

可能的副作用

• Hypersensitivity reactions (vomiting, diarrhea, urticaria, pruritus, dyspnea, hypotension, collapse)
• Hemorrhagic pancreatitis
• Hepatotoxicity
• Coagulation defects
• Hyperglycemia (secondary to altered insulin synthesis)
• Leukopenia (rare)

注意事項與禁忌

• Patients with a history of anaphylaxis to asparaginase
• Patients with pancreatitis or a history of pancreatitis
• Use with caution in patients with preexisting hepatic, renal, hematologic, gastrointestinal, or CNS dysfunction. Intravenous (IV) administration is generally avoided as it significantly increases the risk of anaphylaxis. Premedication with an antihistamine (e.g., diphenhydramine) is strongly recommended. Asparaginase can be a contact irritant; wash off any inadvertent skin contact. May alter thyroid function tests by decreasing thyroxine-binding globulin (TBG).

藥物相互作用

• Methotrexate: Asparaginase may reduce methotrexate effectiveness against tumor cells until serum asparagine levels return to normal.
• Prednisone: Concurrent use may increase the risk for hyperglycemia.
• Vincristine: Increased toxicity (neuropathy and erythropoiesis disruption) and myelosuppression may occur. Some oncologists recommend separating the dosing by a few days to a week.

常見問題